ACTN2 and GATA3

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		ACTN2	GATA3
Description		actinin alpha 2	GATA binding protein 3
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynaptic Density Membrane Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Coactivator Activity Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Titin Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Interleukin-2 Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding HMG Box Domain Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Uncapping Muscle Cell Development Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Cell Fate Determination Neuron Migration Cell Activation Type IV Hypersensitivity Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Kidney Development Mesonephros Development Lens Development In Camera-type Eye Immune System Process Immune System Development Pro-T Cell Differentiation Aortic Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Defense Response Inflammatory Response Humoral Immune Response Signal Transduction Nervous System Development Axon Guidance Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Response To Virus Anatomical Structure Morphogenesis Post-embryonic Development Positive Regulation Of Signal Transduction Response To Gamma Radiation Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Cell Differentiation Neuron Differentiation T Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Regulation Of Epithelial Cell Differentiation TOR Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production T Cell Differentiation In Thymus Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Hemopoiesis Cellular Response To Interferon-alpha Ureter Maturation Parathyroid Hormone Secretion Norepinephrine Biosynthetic Process Inner Ear Morphogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Neuron Apoptotic Process Ear Development Response To Estrogen Thymic T Cell Selection T-helper 2 Cell Differentiation Innate Immune Response Cell Fate Commitment Response To Ethanol Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of T-helper Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Thymus Development Embryonic Organ Development Developmental Growth Anatomical Structure Formation Involved In Morphogenesis System Development Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Regulation Of Developmental Process T Cell Receptor Signaling Pathway Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Parathyroid Gland Development Pharyngeal System Development Uterus Development Canonical Wnt Signaling Pathway Mesenchymal To Epithelial Transition Mast Cell Differentiation Ureteric Bud Formation Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Otic Vesicle Development Cellular Response To BMP Stimulus Positive Regulation Of Ureteric Bud Formation Nephric Duct Morphogenesis Nephric Duct Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Ureter Morphogenesis Lymphocyte Migration Cochlea Development Positive Regulation Of MiRNA Transcription Regulation Of Establishment Of Cell Polarity Negative Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Response To X-ray Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
Pathways		Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Formation of the nephric duct Factors involved in megakaryocyte development and platelet production Developmental Lineage of Mammary Stem Cells
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)	Acute lymphoblastic leukemia (adolescents and young adults) ( 25468567) Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310 30013184) Allergy ( 27182965) Asthma ( 34103634 29273806 27182965 30929738 32296059 31361310 31619474 31959851) Asthma (adult onset) ( 30929738 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune traits (pleiotropy) ( 30572963) B cell acute lymphoblastic leukaemia (abnormal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B cell acute lymphoblastic leukaemia in adulthood ( 29296818) B cell acute lymphoblastic leukaemia in young adulthood ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 25855136 27539887) Benign prostatic hyperplasia and/or lower urinary tract symptoms ( 28656603) Calcium levels ( 24068962) Colorectal cancer ( 30529582 28869801 25990418 24737748 31826910) Colorectal cancer (diet interaction) ( 24743840) Colorectal cancer or advanced adenoma ( 30510241) Craniofacial microsomia ( 26853712) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose change (short-term) ( 31263163) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pleiotropy) ( 31021400) Hair shape ( 29220522) Hodgkin's lymphoma ( 29196614 24920014 21037568) Intracranial aneurysm ( 29531279) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obstetric antiphospholipid syndrome ( 28424481) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Plasma parathyroid hormone levels ( 30134803) Recalcitrant atopic dermatitis ( 25935106) Rheumatoid arthritis ( 23143596 30572963 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Scalp hair shape ( 26926045) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Smoking status (ever vs never smokers) ( 30643258) Stroke ( 26089329) Systemic lupus erythematosus ( 26502338) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 30367059) Type 1 diabetes ( 31152121 34012112)
Interacting Genes		110 interacting genes: ACTN3 ADAM12 ADORA2A AKTIP ANG ANGPTL7 ARX ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CACNA1C CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CIMAP1B CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 FXR1 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SHANK3 SMARCA2 SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TSC1 TSC2 TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2	33 interacting genes: ACTN2 CDK2 CYSRT1 ETS1 ETS2 FBXW7 HDAC2 HDAC3 HIF1A KDM1A KRTAP12-1 KRTAP13-2 KRTAP6-2 KRTAP6-3 LCK LMO1 LMO2 MAPK14 MED1 NFIA NFIB NFIC PLEKHG4 PSMA3 RARB REPIN1 SATB1 SP1 SPI1 TAL1 TRIM55 TRIM63 ZFPM2
Entrez ID		88	2625
HPRD ID		00019	00572
Ensembl ID		ENSG00000077522	ENSG00000107485
Uniprot IDs		P35609	P23771
PDB IDs		1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT 6TS3 7A8T 7A8U 7B55 7B56 7B57	4HC7 4HC9 4HCA
Enriched GO Terms of Interacting Partners?		Z Disc Muscle Alpha-actinin Binding Actin Binding Alpha-actinin Binding Postsynaptic Density Regulation Of Neuronal Synaptic Plasticity Sarcomere Organization Protein Binding Actin Cytoskeleton Actin Filament-based Process Telethonin Binding Organelle Organization Cytoplasm Neuron Projection Actin Cytoskeleton Organization Calmodulin Binding Actomyosin Structure Organization Cytoskeleton Organization Actinin Binding Calcium- And Calmodulin-dependent Protein Kinase Complex FATZ Binding Regulation Of Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Cytoskeletal Protein Binding Regulation Of Synaptic Plasticity Regulation Of Transport Intracellular Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Structural Constituent Of Muscle Cell Adhesion Nuclear Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Metal Ion Transport Regulation Of Signal Transduction Stress Fiber Regulation Of Multicellular Organismal Process Adherens Junction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Kinase Binding Locomotor Rhythm Cell Projection Organization Protein-containing Complex Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium Ion Transport Calcium-mediated Signaling	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Erythrocyte Differentiation Chromatin DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Binding Regulation Of Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Neural Precursor Cell Proliferation Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cell Population Proliferation Regulation Of Hemopoiesis Regulation Of Macromolecule Metabolic Process Generation Of Neurons Positive Regulation Of Chromatin Organization Protein Lysine Delactylase Activity Sequence-specific DNA Binding Positive Regulation Of Blood Vessel Endothelial Cell Migration Embryonic Hemopoiesis Protein Binding Regulation Of Metabolic Process Nucleus
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