ACTN2 and PPP1CB

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		ACTN2	PPP1CB
Description		actinin alpha 2	protein phosphatase 1 catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynaptic Density Membrane Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Focal Adhesion Extracellular Exosome PTW/PP1 Phosphatase Complex
	Molecular Function	Transcription Coactivator Activity Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Titin Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity
	Biological Process	Cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Uncapping Muscle Cell Development Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity	MAPK Cascade Glycogen Metabolic Process Protein Dephosphorylation Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Rhythmic Process Cell Division
Pathways		Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)	Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 28869591 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)
Interacting Genes		110 interacting genes: ACTN3 ADAM12 ADORA2A AKTIP ANG ANGPTL7 ARX ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CACNA1C CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CIMAP1B CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 FXR1 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SHANK3 SMARCA2 SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TSC1 TSC2 TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2	46 interacting genes: ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NONO PHACTR3 PPP1R11 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP2R5C PRKAR2A PTK2 RB1 RORC SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9
Entrez ID		88	5500
HPRD ID		00019	11792
Ensembl ID		ENSG00000077522	ENSG00000213639
Uniprot IDs		P35609	P62140 V9HW04
PDB IDs		1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT 6TS3 7A8T 7A8U 7B55 7B56 7B57
Enriched GO Terms of Interacting Partners?		Z Disc Muscle Alpha-actinin Binding Actin Binding Alpha-actinin Binding Postsynaptic Density Regulation Of Neuronal Synaptic Plasticity Sarcomere Organization Protein Binding Actin Cytoskeleton Actin Filament-based Process Telethonin Binding Organelle Organization Cytoplasm Neuron Projection Actin Cytoskeleton Organization Calmodulin Binding Actomyosin Structure Organization Cytoskeleton Organization Actinin Binding Calcium- And Calmodulin-dependent Protein Kinase Complex FATZ Binding Regulation Of Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Cytoskeletal Protein Binding Regulation Of Synaptic Plasticity Regulation Of Transport Intracellular Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Structural Constituent Of Muscle Cell Adhesion Nuclear Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Metal Ion Transport Regulation Of Signal Transduction Stress Fiber Regulation Of Multicellular Organismal Process Adherens Junction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Kinase Binding Locomotor Rhythm Cell Projection Organization Protein-containing Complex Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium Ion Transport Calcium-mediated Signaling	Myosin Phosphatase Regulator Activity Protein Phosphatase Inhibitor Activity Phosphatase Regulator Activity Protein Phosphatase 1 Binding Glycogen Binding Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Phosphatase Binding Enzyme Inhibitor Activity Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Glycogen Biosynthetic Process Stress Fiber Regulation Of Centromere Complex Assembly Regulation Of Glycogen Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Kinase Binding Centrosome Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromatin Cell Projection Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle A Band Segment Specification Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Process
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