ACTN2 and CRABP2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		ACTN2	CRABP2
Description		actinin alpha 2	cellular retinoic acid binding protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynaptic Density Membrane Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Titin Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity	Retinoic Acid Binding Retinoid Binding Fatty Acid Binding Protein Binding Lipid Binding Retinal Binding Retinol Binding Cyclin Binding
	Biological Process	Cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Uncapping Muscle Cell Development Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity	Regulation Of DNA-templated Transcription Signal Transduction Epidermis Development Fatty Acid Transport Embryonic Forelimb Morphogenesis Retinoic Acid Metabolic Process Positive Regulation Of Collateral Sprouting
Pathways		Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Signaling by Retinoic Acid
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		110 interacting genes: ACTN3 ADAM12 ADORA2A AKTIP ANG ANGPTL7 ARX ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CACNA1C CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CIMAP1B CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 FXR1 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SHANK3 SMARCA2 SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TSC1 TSC2 TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2	4 interacting genes: ACTN2 CCND3 FLAD1 KASH5
Entrez ID		88	1382
HPRD ID		00019	08353
Ensembl ID		ENSG00000077522	ENSG00000143320
Uniprot IDs		P35609	P29373
PDB IDs		1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT 6TS3 7A8T 7A8U 7B55 7B56 7B57	1BLR 1BM5 1CBQ 1CBS 1XCA 2CBS 2FR3 2FRS 2FS6 2FS7 2G78 2G79 2G7B 3CBS 3CR6 3CWK 3D95 3D96 3D97 3F8A 3F9D 3FA6 3FA7 3FA8 3FA9 3FEK 3FEL 3FEN 3FEP 3I17 4I9R 4I9S 4M6S 4M7M 4QGV 4QGW 4QGX 4YBP 4YBU 4YCE 4YCH 4YDA 4YDB 4YFP 4YFQ 4YFR 4YGG 4YGH 4YGZ 4YH0 4YKM 4YKO 5HZQ 5OGB 6HKR 6MOP 6MOQ 6MOR 6MOV 6MOW 6MOX 6MPK 6MQI 6MQJ 6MQW 6MQX 6MQY 6MQZ 6MR0 6NNX 6NNY 6NOE 6Z2U 6Z2Z 6ZSW 6ZSX 7AA0 7AA1 7OXW 7OXX 7RY5
Enriched GO Terms of Interacting Partners?		Z Disc Muscle Alpha-actinin Binding Actin Binding Alpha-actinin Binding Postsynaptic Density Regulation Of Neuronal Synaptic Plasticity Sarcomere Organization Protein Binding Actin Cytoskeleton Actin Filament-based Process Telethonin Binding Organelle Organization Cytoplasm Neuron Projection Actin Cytoskeleton Organization Calmodulin Binding Actomyosin Structure Organization Cytoskeleton Organization Actinin Binding Calcium- And Calmodulin-dependent Protein Kinase Complex FATZ Binding Regulation Of Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Cytoskeletal Protein Binding Regulation Of Synaptic Plasticity Regulation Of Transport Intracellular Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Structural Constituent Of Muscle Cell Adhesion Nuclear Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Metal Ion Transport Regulation Of Signal Transduction Stress Fiber Regulation Of Multicellular Organismal Process Adherens Junction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Kinase Binding Locomotor Rhythm Cell Projection Organization Protein-containing Complex Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium Ion Transport Calcium-mediated Signaling	Titin Z Domain Binding Actin Filament Uncapping Z Disc Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex FMN Adenylyltransferase Activity Flavin Adenine Dinucleotide Biosynthetic Process FAD Biosynthetic Process FAD Diphosphatase Activity Meiotic Spindle Pole Phospholipase C-activating Angiotensin-activated Signaling Pathway Microspike Assembly Small Conductance Calcium-activated Potassium Channel Activity Riboflavin Metabolic Process FATZ Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity LIM Domain Binding Positive Regulation Of Endocytic Recycling Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Postsynaptic Actin Cytoskeleton Meiotic Nuclear Membrane Microtubule Tethering Complex Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Actin Filament Depolymerization Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Calcium-activated Potassium Channel Activity Titin Binding Lateral Element Postsynaptic Actin Cytoskeleton Organization Pseudopodium Postsynaptic Density, Intracellular Component Positive Regulation Of Protein Depolymerization Postsynaptic Cytoskeleton Organization Angiotensin-activated Signaling Pathway Regulation Of Endocytic Recycling Dynein Complex Binding
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