RAD21 and PPP1R15A

Number of citations of the paper that reports this interaction (PubMedID 22145905)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RAD21	PPP1R15A
Description		RAD21 cohesin complex component	protein phosphatase 1 regulatory subunit 15A
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Cohesin Complex Membrane Nuclear Matrix Midbody Mitotic Cohesin Complex Meiotic Cohesin Complex	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding LncRNA Binding DNA-binding Transcription Factor Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Eukaryotic Initiation Factor EIF2 Binding Protein Phosphatase Activator Activity
	Biological Process	Response To Hypoxia DNA Repair Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Chromosome Segregation Sister Chromatid Cohesion Reciprocal Meiotic Recombination Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Regulation Of Translation Regulation Of Translational Initiation Apoptotic Process DNA Damage Response Positive Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80	16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		5885	23645
HPRD ID		05924	06572
Ensembl ID		ENSG00000164754	ENSG00000087074
Uniprot IDs		O60216	O75807
PDB IDs		4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE 7W1M 7ZJS 8K4D 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG 8ROH 8ROI 8ROJ 8ROK 8ROL	4XPN 7NXV 7NZM 8QZZ
Enriched GO Terms of Interacting Partners?		Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Spindle Assembly Microtubule Cytoskeleton Organization Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Organization Chromosome Segregation Spindle Organization Cytosol Microtubule-based Process Sister Chromatid Cohesion Mitotic Spindle Assembly Negative Regulation Of Cell Size Membraneless Organelle Assembly Cell Division Establishment Of Spindle Localization Cytosolic Large Ribosomal Subunit RNA Binding Spindle Localization Chromosome, Centromeric Region Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Cell Size Positive Regulation Of Proteolysis Actin Binding Regulation Of Proteolysis Mitotic Spindle Organization Cytosolic Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ficolin-1-rich Granule Lumen Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Regulation Of Cellular Component Size Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Cell-matrix Adhesion Positive Regulation Of Protein Localization To Cell Leading Edge Cortical Microtubule Meiotic Cell Cycle Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Chromosome Organelle Assembly	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Translational Initiation In Response To Stress Cellular Response To Heat Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Heat Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translational Initiation Viral Genome Replication Regulation Of Translation In Response To Stress Protein-containing Complex Binding Response To Temperature Stimulus Nucleus Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Translation Initiation Ternary Complex Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Metanephric DCT Cell Differentiation Cell Division Metanephric Macula Densa Development Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Transcription Initiation-coupled Chromatin Remodeling B Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Regulation Of Metabolic Process Protein Stabilization Positive Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Glycogen Metabolic Process Positive Regulation Of Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Protein Metabolic Process Denatured Protein Binding Positive Regulation Of Oligodendrocyte Progenitor Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Metanephric Thick Ascending Limb Development
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