RAD21 and CASP7

Number of citations of the paper that reports this interaction (PMID 11875078)
17

Data Source:
HPRD (in vitro)

		RAD21	CASP7
Gene Name		RAD21 homolog (S. pombe)	caspase 7, apoptosis-related cysteine peptidase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Meiotic Cohesin Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair DNA Recombination Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Chromosome Segregation Mitotic Nuclear Division Reciprocal Meiotic Recombination Cell Division Protein Localization To Chromatin	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase	Activation of caspases through apoptosome-mediated cleavage Apoptotic cleavage of cellular proteins Apoptotic factor-mediated response SMAC binds to IAPs Apoptotic execution phase Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins Intrinsic Pathway for Apoptosis
Drugs			Fica
Diseases
GWAS			Vitiligo ( 22561518)
Protein-Protein Interactions		28 interactors: CAPN1 CASP7 CFL1 COX2 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 NUMA1 PPP1R15A PPP1R15B RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 TMSB4X TNFRSF14 WAPAL WNT2B ZNF80	60 interactors: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAPT MAX MEF2A MEF2D NEDD4 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP
Entrez ID		5885	840
HPRD ID		05924	03457
Ensembl ID		ENSG00000164754	ENSG00000165806
Uniprot IDs		O60216	B4DWA2 P55210
PDB IDs			1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2
Enriched GO Terms of Interacting Partners?		Cell Division Mitotic Nuclear Division Cellular Protein Localization Viral Life Cycle Cytoskeleton Organization Mitotic Cell Cycle Process Negative Regulation Of DNA Endoreduplication Protein Localization To Endoplasmic Reticulum Cell Cycle Process Mitotic Cell Cycle Organelle Organization Protein Localization To Organelle Negative Regulation Of DNA Replication MRNA Metabolic Process Viral Process Protein Localization Cellular Localization Cellular Protein Complex Disassembly Regulation Of DNA Endoreduplication Protein Complex Disassembly Cell Cycle Negative Regulation Of Cell Cycle Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Establishment Of Cell Polarity Negative Regulation Of DNA Metabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of DNA Replication Sister Chromatid Cohesion Establishment Of Mitotic Spindle Orientation Actin Cytoskeleton Organization Translational Termination Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Establishment Of Protein Localization To Organelle Nuclear-transcribed MRNA Catabolic Process Actin Filament-based Process MRNA Catabolic Process Protein Targeting To Membrane Establishment Or Maintenance Of Cell Polarity Viral Entry Into Host Cell Translational Elongation Spindle Localization Regulation Of Metabolic Process Entry Into Host Cell RNA Catabolic Process Positive Regulation Of Translational Initiation In Response To Stress	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Response To Stimulus Regulation Of Cellular Component Organization Cell Communication Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Signaling Myeloid Cell Differentiation System Development Regulation Of Metabolic Process Cellular Response To Organic Substance Viral Process Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Peptidase Activity Anatomical Structure Development Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Multicellular Organismal Development Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		aberrations apart aspect ccnd1 clinicopathological copy covered encompassed endometrial erbb1 erbb2 erbb3 erbb4 esr1 frequent infiltration insufficient myometrial pakt1 pgr pik3ca prom1 rad27 runx1 scgb2a2 snai1 snai2 top2a younger	balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds
Tagcloud (Difference) ?		aberrations apart aspect ccnd1 clinicopathological copy covered encompassed endometrial erbb1 erbb2 erbb3 erbb4 esr1 frequent infiltration insufficient myometrial pakt1 pgr pik3ca prom1 rad27 runx1 scgb2a2 snai1 snai2 top2a younger	balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds
Tagcloud (Intersection) ?