LPA and FBLN5

Number of citations of the paper that reports this interaction (PubMedID 12111551)
0

Data Source:
HPRD (two hybrid, in vivo)

		LPA	FBLN5
Description		lipoprotein(a)	fibulin 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Lipoprotein Particle	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Fibronectin Binding Serine-type Endopeptidase Activity Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Apolipoprotein Binding	Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Proteolysis Lipid Metabolic Process Lipid Transport Blood Circulation	Negative Regulation Of Transcription By RNA Polymerase II Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals
Pathways		LDL remodeling	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Aminocaproic acid
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		A body shape index ( 34021172) Abdominal aortic aneurysm ( 32981348) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Aortic valve stenosis ( 29511194) Aortic-valve calcification ( 23388002) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) C-reactive protein levels ( 33339817) Calcific aortic valve stenosis ( 32141789) Cholesterol, total ( 20686565 24097068 25961943 28270201) Coronary artery disease ( 24262325 26343387 28714974 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease in diabetes ( 30003307) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 19198611 21378990) End stage renal disease x APOL1 genotype interaction ( 29885931) HDL cholesterol ( 20686565 25961943) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 26377243 28512139 30108283 33115273 33730874) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lp (a) levels ( 19124843 21900290) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Medication use (vasodilators used in cardiac diseases) ( 31015401) Metabolic syndrome ( 31589552) Minimum ankle–brachial index ( 31285632) Monocyte early outgrowth colony forming units ( 21493818) Myocardial infarction ( 26343387 33532862) Parental lifespan ( 29030599 30642433) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965 31484785) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Parental longevity (mother's age at death) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 31285632) Plasma plasminogen levels ( 25208887) Plateletcrit ( 32888494) Protein quantitative trait loci ( 18464913) Response to statin therapy ( 22368281) Response to statins (LDL cholesterol change) ( 22331829 25350695) Total cholesterol levels ( 28334899 30275531 33339817) Triglyceride levels ( 32154731 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 25961943 30275531) Urinary albumin excretion ( 32277301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 18391951 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		9 interacting genes: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12	13 interacting genes: ATN1 GFI1B HOXA1 LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PRNP SOD3 TOP3B TRIP13
Entrez ID		4018	10516
HPRD ID		01063	05204
Ensembl ID		ENSG00000198670	ENSG00000140092
Uniprot IDs		P08519	A0A024R6G3 A0A9L9PXD9 G3V2P8 G3V4U0 G3XA98 Q9UBX5
PDB IDs		1I71 1JFN 1KIV 2FEB 3KIV 4BV5 4BV7 4BVC 4BVD 4BVV 4BVW 4KIV 6RX7 8TCE 8V8Z 8V9B
Enriched GO Terms of Interacting Partners?		Protein Activation Cascade Extracellular Space Elastin Catabolic Process Extracellular Matrix Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Elastin Metabolic Process Regulation Of Multicellular Organismal Process Proteolysis Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Extracellular Exosome Extracellular Region Plasminogen Activation Cell-matrix Adhesion Response To Leptin Positive Regulation Of Cell Population Proliferation Serine-type Endopeptidase Activity Heparin Binding Cell-substrate Adhesion Protein Metabolic Process Glycoprotein Catabolic Process Negative Regulation Of Multicellular Organismal Process Zymogen Activation Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Cell-substrate Adhesion Protein Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Disassembly Negative Regulation Of Hemostasis Positive Regulation Of Metabolic Process Negative Regulation Of Coagulation Regulation Of Multicellular Organismal Development Protein Maturation Regulation Of Angiogenesis Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Collagen Binding Intramembranous Bone Growth Regulation Of Vasculature Development Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Anatomical Structure Morphogenesis	Copper Ion Binding Nuclear Matrix Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Heparin Binding Plasma Lipoprotein Particle Diencephalon Morphogenesis Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protease Binding Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Glycosaminoglycan Binding Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Type 8 Metabotropic Glutamate Receptor Binding Dendritic Spine Organization Negative Regulation Of Interleukin-2 Production Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis RNA Topoisomerase Activity Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Negative Regulation Of Type II Interferon Production Postsynapse Organization
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