| Name |
lipoprotein(a) |
LDL receptor related protein 2 |
| Structure |
|
|
| GO Annotations |
Cellular Component |
|
|
| Molecular Function |
|
|
| Biological Process |
|
|
| Pathways |
|
|
| Drugs |
|
|
| Diseases |
None
|
|
| GWAS |
- A body shape index ( 34021172
)
- Abdominal aortic aneurysm ( 32981348
)
- Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081
)
- Aortic valve stenosis ( 29511194
)
- Aortic-valve calcification ( 23388002
)
- Apolipoprotein A1 levels ( 32203549
)
- Apolipoprotein B levels ( 32203549
)
- Body mass index ( 26426971
)
- Body mass index (age>50) ( 26426971
)
- Body mass index x sex x age interaction (4df test) ( 26426971
)
- C-reactive protein levels ( 33339817
)
- Calcific aortic valve stenosis ( 32141789
)
- Cholesterol, total ( 20686565
24097068
25961943
28270201
)
- Coronary artery disease ( 24262325
26343387
28714974
29212778
32469254
33020668
)
- Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975
)
- Coronary artery disease in diabetes ( 30003307
)
- Coronary artery disease or ischemic stroke ( 24262325
)
- Coronary artery disease or large artery stroke ( 24262325
)
- Coronary heart disease ( 19198611
21378990
)
- End stage renal disease x APOL1 genotype interaction ( 29885931
)
- HDL cholesterol ( 20686565
25961943
)
- HDL cholesterol levels ( 32203549
)
- HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716
)
- HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716
)
- Heart failure ( 31919418
)
- High density lipoprotein cholesterol levels ( 33339817
)
- Hip circumference adjusted for BMI ( 34021172
)
- LDL cholesterol ( 20686565
24097068
25961943
30275531
)
- LDL cholesterol levels ( 32203549
)
- LDL cholesterol levels in current drinkers ( 30698716
)
- LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716
)
- LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716
)
- Lipid or lipoprotein levels ( 23696881
)
- Lipoprotein (a) levels ( 26377243
28512139
30108283
33115273
33730874
)
- Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284
)
- Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334
)
- Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643
)
- Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139
)
- Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302
)
- Low density lipoprotein cholesterol levels ( 32154731
33339817
)
- Lp (a) levels ( 19124843
21900290
)
- Medication use (agents acting on the renin-angiotensin system) ( 31015401
)
- Medication use (antithrombotic agents) ( 31015401
)
- Medication use (beta blocking agents) ( 31015401
)
- Medication use (HMG CoA reductase inhibitors) ( 31015401
)
- Medication use (salicylic acid and derivatives) ( 31015401
)
- Medication use (vasodilators used in cardiac diseases) ( 31015401
)
- Metabolic syndrome ( 31589552
)
- Minimum ankle–brachial index ( 31285632
)
- Monocyte early outgrowth colony forming units ( 21493818
)
- Myocardial infarction ( 26343387
33532862
)
- Parental lifespan ( 29030599
30642433
)
- Parental longevity (both parents in top 10%) ( 29227965
)
- Parental longevity (combined parental age at death) ( 29227965
)
- Parental longevity (combined parental attained age, Martingale residuals) ( 29227965
)
- Parental longevity (father's age at death) ( 29227965
31484785
)
- Parental longevity (father's attained age) ( 29227965
)
- Parental longevity (mother's age at death or mother's attained age) ( 31484785
)
- Parental longevity (mother's age at death) ( 29227965
)
- Parental longevity (mother's attained age) ( 29227965
)
- Peripheral artery disease ( 31285632
)
- Plasma plasminogen levels ( 25208887
)
- Plateletcrit ( 32888494
)
- Protein quantitative trait loci ( 18464913
)
- Response to statin therapy ( 22368281
)
- Response to statins (LDL cholesterol change) ( 22331829
25350695
)
- Total cholesterol levels ( 28334899
30275531
33339817
)
- Triglyceride levels ( 32154731
32203549
)
- Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716
)
- Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716
)
- Triglycerides ( 25961943
30275531
)
- Urinary albumin excretion ( 32277301
)
- Waist-hip index ( 34021172
)
- Waist-to-hip ratio adjusted for BMI ( 34021172
)
|
|
| Novel Interactors |
None recorded
|
6 novel interactors:
COL3A1
EIPR1
GALNT3
HK3
TANK
TBR1
|
| Interacting Genes |
9 interacting genes:
APOH
CANX
CELA1
ELANE
FBLN5
FGB
FN1
LRP2
MMP12
|
53 interacting genes:
ALB
ANAPC10
ANKRA2
ANKS1B
APBA2
APBB1
APOB
APOE
APOH
APP
ATN1
CDC42
CLU
CUBN
DAB1
DAB2
DLG1
DLG2
DLG3
DLG4
DYRK1A
GC
GIPC1
GPRASP1
INS
ITGB1BP1
LCN2
LDLRAP1
LPA
LPL
LRP2BP
LRPAP1
MAGI1
MAPK8IP1
MAPK8IP2
MDK
NOS1AP
PIP5K1C
PLAU
RAC1
RBP1
RHOA
SCGB1A1
SCN3A
SERPINE1
SLC9A3
SNX17
SYNJ2BP
TG
THBS1
TLN1
TTR
USP40
|
| Entrez ID |
4018 |
4036 |
| HPRD ID |
01063
|
02509
|
| Ensembl ID |
ENSG00000198670
|
ENSG00000081479
|
| Uniprot IDs |
P08519
|
P98164
Q7Z5C0
Q7Z5C1
|
| PDB IDs |
1I71
1JFN
1KIV
2FEB
3KIV
4BV5
4BV7
4BVC
4BVD
4BVV
4BVW
4KIV
6RX7
8TCE
8V8Z
8V9B
|
2M0P
|
| GO Terms Enriched among Interactors |
|
|