LPA and ELANE

Number of citations of the paper that reports this interaction (PubMedID 9111002)
0

Data Source:
HPRD (in vitro)

		LPA	ELANE
Description		lipoprotein(a)	elastase, neutrophil expressed
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Lipoprotein Particle	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Fibronectin Binding Serine-type Endopeptidase Activity Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Apolipoprotein Binding	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding
	Biological Process	Proteolysis Lipid Metabolic Process Lipid Transport Blood Circulation	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		LDL remodeling	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes
Drugs		Aminocaproic acid	Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		A body shape index ( 34021172) Abdominal aortic aneurysm ( 32981348) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Aortic valve stenosis ( 29511194) Aortic-valve calcification ( 23388002) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) C-reactive protein levels ( 33339817) Calcific aortic valve stenosis ( 32141789) Cholesterol, total ( 20686565 24097068 25961943 28270201) Coronary artery disease ( 24262325 26343387 28714974 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease in diabetes ( 30003307) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 19198611 21378990) End stage renal disease x APOL1 genotype interaction ( 29885931) HDL cholesterol ( 20686565 25961943) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 26377243 28512139 30108283 33115273 33730874) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lp (a) levels ( 19124843 21900290) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Medication use (vasodilators used in cardiac diseases) ( 31015401) Metabolic syndrome ( 31589552) Minimum ankle–brachial index ( 31285632) Monocyte early outgrowth colony forming units ( 21493818) Myocardial infarction ( 26343387 33532862) Parental lifespan ( 29030599 30642433) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965 31484785) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Parental longevity (mother's age at death) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 31285632) Plasma plasminogen levels ( 25208887) Plateletcrit ( 32888494) Protein quantitative trait loci ( 18464913) Response to statin therapy ( 22368281) Response to statins (LDL cholesterol change) ( 22331829 25350695) Total cholesterol levels ( 28334899 30275531 33339817) Triglyceride levels ( 32154731 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 25961943 30275531) Urinary albumin excretion ( 32277301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576)
Interacting Genes		9 interacting genes: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12	31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		4018	1991
HPRD ID		01063	00554
Ensembl ID		ENSG00000198670	ENSG00000197561
Uniprot IDs		P08519	P08246
PDB IDs		1I71 1JFN 1KIV 2FEB 3KIV 4BV5 4BV7 4BVC 4BVD 4BVV 4BVW 4KIV 6RX7 8TCE 8V8Z 8V9B	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU
Enriched GO Terms of Interacting Partners?		Protein Activation Cascade Extracellular Space Elastin Catabolic Process Extracellular Matrix Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Elastin Metabolic Process Regulation Of Multicellular Organismal Process Proteolysis Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Extracellular Exosome Extracellular Region Plasminogen Activation Cell-matrix Adhesion Response To Leptin Positive Regulation Of Cell Population Proliferation Serine-type Endopeptidase Activity Heparin Binding Cell-substrate Adhesion Protein Metabolic Process Glycoprotein Catabolic Process Negative Regulation Of Multicellular Organismal Process Zymogen Activation Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Cell-substrate Adhesion Protein Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Disassembly Negative Regulation Of Hemostasis Positive Regulation Of Metabolic Process Negative Regulation Of Coagulation Regulation Of Multicellular Organismal Development Protein Maturation Regulation Of Angiogenesis Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Collagen Binding Intramembranous Bone Growth Regulation Of Vasculature Development Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Anatomical Structure Morphogenesis	Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process
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