LPA and ELANE

Number of citations of the paper that reports this interaction (PMID 8864963)
3

Data Source:
HPRD (in vitro)

		LPA	ELANE
Gene Name		lipoprotein, Lp(a)	elastase, neutrophil expressed
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Lipoprotein Particle	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Serine-type Endopeptidase Activity Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Apolipoprotein Binding	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding
	Biological Process	Proteolysis Lipid Metabolic Process Lipid Transport Receptor-mediated Endocytosis Blood Circulation Negative Regulation Of Endopeptidase Activity Lipoprotein Metabolic Process Small Molecule Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Aminocaproic Acid	Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS		Aortic-valve calcification ( 23388002) Cholesterol, total ( 20686565) Coronary heart disease ( 19198611 21378990) HDL cholesterol ( 20686565) LDL cholesterol ( 20686565) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Lp (a) levels ( 21900290 19124843) Monocyte early outgrowth colony forming units ( 21493818) Protein quantitative trait loci ( 18464913) Response to statin therapy ( 22368281) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		9 interactors: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12	30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS
Entrez ID		4018	1991
HPRD ID		01063	00554
Ensembl ID		ENSG00000198670	ENSG00000197561
Uniprot IDs			P08246
PDB IDs			1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Wound Healing Response To Wounding Extracellular Matrix Disassembly Blood Coagulation Hemostasis Cell-matrix Adhesion Response To Stress Regulation Of Body Fluid Levels Secretion Cell-substrate Adhesion Vesicle-mediated Transport Collagen Catabolic Process Platelet Degranulation Acute Inflammatory Response Collagen Metabolic Process Transport Multicellular Organismal Macromolecule Metabolic Process Inflammatory Response Multicellular Organismal Metabolic Process Secretion By Cell Neutrophil Mediated Killing Of Fungus Protein Metabolic Process Defense Response Triglyceride Transport Response To Stimulus Regulation Of Growth Regulation Of Cell Proliferation Calcium-independent Cell-matrix Adhesion Endocytosis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Pancreas Morphogenesis Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Platelet Activation Elastic Fiber Assembly Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Cell Migration Leukocyte Migration Plasminogen Activation Acute Inflammatory Response To Antigenic Stimulus Exocrine Pancreas Development Negative Regulation Of Locomotion Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Fibrinolysis	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation
Tagcloud ?		adequacy amplified apl attributable cdna concordance disagreement ensure external hematological hospitals implementation inadequacy laboratories malignancies participating pethema pml promyelocytic rearrangements rr satisfactorily scheme sent spanish standardization standardize stressed supporting	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Difference) ?		adequacy amplified apl attributable cdna concordance disagreement ensure external hematological hospitals implementation inadequacy laboratories malignancies participating pethema pml promyelocytic rearrangements rr satisfactorily scheme sent spanish standardization standardize stressed supporting	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Intersection) ?