CCDC88A and KDR

Number of citations of the paper that reports this interaction (PubMedID 25187647)
82

Data Source:
BioGRID (pull down)

		CCDC88A	KDR
Description		coiled-coil and HOOK domain protein 88A	kinase insert domain receptor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cell Leading Edge Cytoplasmic Vesicle Ciliary Basal Body Cell Projection	Extracellular Region Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Receptor Complex Membrane Raft Anchoring Junction Cell Periphery Sorting Endosome
	Molecular Function	G-protein Alpha-subunit Binding Actin Binding Protein Kinase C Binding Guanyl-nucleotide Exchange Factor Activity GDP-dissociation Inhibitor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Microtubule Binding Phosphatidylinositol Binding SH2 Domain Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Kinase B Binding Protein Serine/threonine Kinase Activator Activity Dynein Light Intermediate Chain Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Integrin Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Growth Factor Binding Vascular Endothelial Growth Factor Binding Identical Protein Binding Cadherin Binding Hsp90 Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Cell Migration Cell Projection Organization Lamellipodium Assembly Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization TOR Signaling Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Population Proliferation Positive Regulation Of Cilium Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Organization Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Localization To Cilium	Angiogenesis Ovarian Follicle Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Maturation Endocardium Development Endothelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Mesenchymal Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Cell Migration Peptidyl-tyrosine Phosphorylation Hemopoiesis Cell Differentiation Lung Development Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Embryonic Hemopoiesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Post-embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Calcium Ion Homeostasis Epithelial Tube Morphogenesis Blood Vessel Endothelial Cell Differentiation Vascular Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Stem Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Bone Development Cellular Response To Hydrogen Sulfide Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Vasculogenesis
Pathways		RND3 GTPase cycle RND1 GTPase cycle	Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization Integrin cell surface interactions VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Sorafenib Sunitinib 1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Cediranib Vatalanib XL999 TG-100801 XL820 CYC116 Ramucirumab Pegdinetanib RAF-265 Linifanib IMC-1C11 Semaxanib Pazopanib Midostaurin Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib Lenvatinib Nintedanib Tivozanib Fostamatinib Erdafitinib Foretinib Ripretinib Pralsetinib Olinvacimab
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 21998595) Periventricular white matter hyperintensities ( 32517579) Refractive error ( 32231278)	Blood protein levels ( 30072576) Endometriosis ( 28537267) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FVC) ( 30804560) Mosquito bite size ( 28199695) Peak expiratory flow ( 30804560) Serum VEGFR2 concentration ( 25411163) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: AKT1 BRAF CTNNA2 CTNNB1 DISC1 EGFR EXOC1 GNAI3 INSR KDR NDEL1 PRKACA PTPN6	63 interacting genes: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CCDC88A CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 DUSP19 FBXO25 FBXW11 FLT1 FLT4 FRS2 FYN GABARAP GNA11 GNAQ GRB10 GRB2 HSP90AA1 ILKAP IQGAP1 ITGB3 KPNA4 MAPK1 NCK1 NRP1 P2RY2 PDCL3 PLCG1 PLCG2 PPM1A PPM1B PTPN11 PTPN12 PTPN6 PTPRR RASA1 SERPINF1 SH2D2A SHB SHC1 SHC2 SNCA SRC STAT1 STYX SYNGAP1 TIMP3 USP7 VEGFA VEGFC VEGFD YES1
Entrez ID		55704	3791
HPRD ID		11131	01867
Ensembl ID		ENSG00000115355	ENSG00000128052
Uniprot IDs		O14997 Q3V6T2	P35968
PDB IDs		6MHF	1VR2 1Y6A 1Y6B 1YWN 2M59 2MET 2MEU 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 3WZD 3WZE 4AG8 4AGC 4AGD 4ASD 4ASE 5EW3 5OYJ 6GQO 6GQP 6GQQ 6XVJ 6XVK
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Ciliary Basal Body Cell Surface Receptor Signaling Pathway Phosphorylation Regulation Of Macroautophagy ERBB Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Protein Kinase Activity Animal Organ Morphogenesis Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Growth Factor Stimulus Cell Migration Cerebral Cortex Cell Migration Positive Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Kinase Activity Regulation Of Cell Differentiation Cell Motility Regulation Of MAPK Cascade Telencephalon Cell Migration Positive Regulation Of D-glucose Transmembrane Transport Embryonic Organ Development Forebrain Cell Migration Positive Regulation Of Glucose Metabolic Process Regulation Of Autophagy Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Radial Glia-guided Pyramidal Neuron Migration Regulation Of Developmental Process Identical Protein Binding Signal Transduction Regulation Of Neuron Projection Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Positive Regulation Of MAPK Cascade	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Cytoplasm Regulation Of Vasculature Development Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor 2 Binding Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Programmed Cell Death Response To Platelet-derived Growth Factor T Cell Costimulation Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Population Proliferation Cell Motility SH3 Domain Binding Developmental Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Cytosol Ephrin Receptor Signaling Pathway Focal Adhesion Immune Response-activating Signaling Pathway Protein Dephosphorylation
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