CCDC88A and GNAI3

Number of citations of the paper that reports this interaction (PubMedID 26126266)
145

Data Source:
BioGRID (pull down)

		CCDC88A	GNAI3
Description		coiled-coil and HOOK domain protein 88A	G protein subunit alpha i3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cell Leading Edge Cytoplasmic Vesicle Ciliary Basal Body Cell Projection	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Actin Binding Protein Kinase C Binding Guanyl-nucleotide Exchange Factor Activity GDP-dissociation Inhibitor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Microtubule Binding Phosphatidylinositol Binding SH2 Domain Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Kinase B Binding Protein Serine/threonine Kinase Activator Activity Dynein Light Intermediate Chain Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Cell Migration Cell Projection Organization Lamellipodium Assembly Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization TOR Signaling Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Population Proliferation Positive Regulation Of Cilium Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Organization Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Localization To Cilium	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division
Pathways		RND3 GTPase cycle RND1 GTPase cycle	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 21998595) Periventricular white matter hyperintensities ( 32517579) Refractive error ( 32231278)	Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)
Interacting Genes		13 interacting genes: AKT1 BRAF CTNNA2 CTNNB1 DISC1 EGFR EXOC1 GNAI3 INSR KDR NDEL1 PRKACA PTPN6	45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR
Entrez ID		55704	2773
HPRD ID		11131	00765
Ensembl ID		ENSG00000115355	ENSG00000065135
Uniprot IDs		O14997 Q3V6T2	P08754
PDB IDs		6MHF	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Ciliary Basal Body Cell Surface Receptor Signaling Pathway Phosphorylation Regulation Of Macroautophagy ERBB Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Protein Kinase Activity Animal Organ Morphogenesis Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Growth Factor Stimulus Cell Migration Cerebral Cortex Cell Migration Positive Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Kinase Activity Regulation Of Cell Differentiation Cell Motility Regulation Of MAPK Cascade Telencephalon Cell Migration Positive Regulation Of D-glucose Transmembrane Transport Embryonic Organ Development Forebrain Cell Migration Positive Regulation Of Glucose Metabolic Process Regulation Of Autophagy Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Radial Glia-guided Pyramidal Neuron Migration Regulation Of Developmental Process Identical Protein Binding Signal Transduction Regulation Of Neuron Projection Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Positive Regulation Of MAPK Cascade	G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior
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