CCDC88A and CTNNA2

Number of citations of the paper that reports this interaction (PubMedID 30194792)
50

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CCDC88A	CTNNA2
Description		coiled-coil and HOOK domain protein 88A	catenin alpha 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cell Leading Edge Cytoplasmic Vesicle Ciliary Basal Body Cell Projection	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Basolateral Plasma Membrane Catenin Complex Lamellipodium Axon Cell Projection Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Postsynaptic Density, Intracellular Component
	Molecular Function	G-protein Alpha-subunit Binding Actin Binding Protein Kinase C Binding Guanyl-nucleotide Exchange Factor Activity GDP-dissociation Inhibitor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Microtubule Binding Phosphatidylinositol Binding SH2 Domain Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Kinase B Binding Protein Serine/threonine Kinase Activator Activity Dynein Light Intermediate Chain Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Identical Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Cell Migration Cell Projection Organization Lamellipodium Assembly Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization TOR Signaling Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Population Proliferation Positive Regulation Of Cilium Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Organization Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Localization To Cilium	Cytoskeleton Organization Cell Adhesion Axonogenesis Regulation Of Neuron Projection Development Cell Migration Radial Glia Guided Migration Of Purkinje Cell Cell Differentiation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendrite Morphogenesis Brain Morphogenesis Regulation Of Synapse Structural Plasticity Prepulse Inhibition Cell-cell Adhesion Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Neuron Migration
Pathways		RND3 GTPase cycle RND1 GTPase cycle	Myogenesis Myogenesis
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 21998595) Periventricular white matter hyperintensities ( 32517579) Refractive error ( 32231278)	Adult body size ( 32376654) Alcohol consumption ( 28937693) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 19416921) Body mass index ( 25673413 26426971) Bone mineral density (femoral neck) ( 26911590) Breast cancer ( 25824743) Cerebral microbleeds ( 31209788) Cerebrospinal fluid clusterin levels ( 26545630) Cleft palate ( 30452639) Cognitive function ( 25644384) Contrast sensitivity ( 24152035) Cooked vegetable consumption ( 32066663) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Bacteroides) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels in HIV infection ( 33109212) Mild influenza (H1N1) infection ( 26379185) Multisite chronic pain ( 31194737 33830993) Orthostatic hypotension ( 24124408) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Protein quantitative trait loci ( 18464913) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to lurasidone in schizophrenia ( 29730043) Schizophrenia (MTAG) ( 32107650) Survival in pancreatic cancer ( 28470677)
Interacting Genes		13 interacting genes: AKT1 BRAF CTNNA2 CTNNB1 DISC1 EGFR EXOC1 GNAI3 INSR KDR NDEL1 PRKACA PTPN6	3 interacting genes: CCDC88A CTNNBIP1 PTPN14
Entrez ID		55704	1496
HPRD ID		11131	00228
Ensembl ID		ENSG00000115355	ENSG00000066032
Uniprot IDs		O14997 Q3V6T2	F6KRI5 P26232 Q49AD3
PDB IDs		6MHF	6DUW
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Ciliary Basal Body Cell Surface Receptor Signaling Pathway Phosphorylation Regulation Of Macroautophagy ERBB Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Protein Kinase Activity Animal Organ Morphogenesis Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Growth Factor Stimulus Cell Migration Cerebral Cortex Cell Migration Positive Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Kinase Activity Regulation Of Cell Differentiation Cell Motility Regulation Of MAPK Cascade Telencephalon Cell Migration Positive Regulation Of D-glucose Transmembrane Transport Embryonic Organ Development Forebrain Cell Migration Positive Regulation Of Glucose Metabolic Process Regulation Of Autophagy Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Radial Glia-guided Pyramidal Neuron Migration Regulation Of Developmental Process Identical Protein Binding Signal Transduction Regulation Of Neuron Projection Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Positive Regulation Of MAPK Cascade	Regulation Of Protein Localization Maintenance Of Protein Location In Plasma Membrane Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Beta-catenin-ICAT Complex
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