CCDC88A and BRAF

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		CCDC88A	BRAF
Gene Name		coiled-coil domain containing 88A	B-Raf proto-oncogene, serine/threonine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Lamellipodium Cytoplasmic Vesicle	Nucleus Mitochondrion Cytosol Plasma Membrane Neuron Projection Cell Body
	Molecular Function	Actin Binding Microtubule Binding Phosphatidylinositol Binding Protein Homodimerization Activity Protein Kinase B Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Protein Phosphorylation DNA Replication Regulation Of DNA Replication Regulation Of Neuron Projection Development Cell Migration Lamellipodium Assembly TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Proliferation Membrane Organization	MAPK Cascade Activation Of MAPKK Activity Myeloid Progenitor Cell Differentiation Protein Phosphorylation Small GTPase Mediated Signal Transduction Synaptic Transmission Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-serine Phosphorylation Somatic Stem Cell Maintenance Cellular Response To Drug Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process CD4-positive, Alpha-beta T Cell Differentiation Positive T Cell Selection Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Positive Regulation Of Stress Fiber Assembly Response To CAMP Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Signalling to ERKs Prolonged ERK activation events Signalling by NGF Signaling by FGFR in disease NGF signalling via TRKA from the plasma membrane Spry regulation of FGF signaling CREB phosphorylation through the activation of Ras Signaling by FGFR ARMS-mediated activation Activation of NMDA receptor upon glutamate binding and postsynaptic events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signalling to p38 via RIT and RIN Frs2-mediated activation Transmission across Chemical Synapses Post NMDA receptor activation events Negative regulation of FGFR signaling
Drugs			Sorafenib N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime Vemurafenib Regorafenib Dabrafenib
Diseases
GWAS		Height ( 21998595)	Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		6 interactors: AKT1 BRAF DISC1 EXOC1 NDEL1 PRKACA	25 interactors: AKT1 BAD CCDC88A HRAS MAP2K1 MAP2K2 MAPK1 MRAS NEDD4L OIP5 PAK2 PRKACA PRKCE RAF1 RAP1A RAP1GAP RHEB RPS6KB2 SGK1 TERF1 YWHAB YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		55704	673
HPRD ID		11131	01264
Ensembl ID		ENSG00000115355	ENSG00000157764
Uniprot IDs		O14997 Q3V6T2	P15056
PDB IDs			1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4DBN 4E26 4E4X 4EHE 4EHG 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Positive Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cell Development Membrane Organization Positive Regulation Of Protein Modification Process Nuclear Envelope Disassembly Regulation Of Blood Vessel Endothelial Cell Migration Response To Light Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Cerebral Cortex Radially Oriented Cell Migration Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Nuclear Envelope Organization Regulation Of Glucose Import Positive Regulation Of Signal Transduction Endomembrane System Organization Regulation Of Signal Transduction Response To Radiation Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Response To Peptide Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Organ Development Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell Development Regulation Of Endothelial Cell Proliferation Cerebral Cortex Cell Migration Regulation Of Signaling Regulation Of Cell Proliferation Regulation Of Neuron Differentiation Organelle Organization Positive Regulation Of Catalytic Activity Telencephalon Cell Migration Positive Regulation Of Transferase Activity	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Regulation Of Cellular Localization Regulation Of Intracellular Transport Cell Death Death Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Activation Of MAPKK Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Cellular Response To Peptide Cellular Response To Insulin Stimulus Positive Regulation Of Phosphorylation Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Communication Insulin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity
Tagcloud ?			al araf augmentation craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Difference) ?			al araf augmentation craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Intersection) ?