NDC80 and STX11

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NDC80	STX11
Gene Name		NDC80 kinetochore complex component	syntaxin 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex	Golgi Apparatus Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane SNARE Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore	Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Membrane Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Vesicle Docking Membrane Fusion
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT	62 interactors: AES APP BLOC1S6 BYSL C1orf109 CARD9 CCBE1 CCDC184 CCDC33 CCNK CDCA7L CTBP2 CWF19L2 EIF1AD FAM110A FAM161A FAM74A4 FAM90A1 FARS2 FHL5 GOLGA8EP GOLGA8F HAUS1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KLC3 KXD1 LENG1 LONRF1 MBIP MEOX2 MFAP1 MID2 NDC80 PPP1R18 PRKAB2 PRPF31 PSMA3 PSMC3 RUNX1T1 SH2D4A SLC38A2 SMARCE1 SNAP23 SNAP25 SNX3 STXBP1 SUV39H1 TAF6L TBK1 TCF4 TNFRSF21 USHBP1 VAMP2 VPS52 WDYHV1 ZCCHC10 ZNF417 ZNF587
Entrez ID		10403	8676
HPRD ID		06277	09231
Ensembl ID		ENSG00000080986
Uniprot IDs		A8K031 O14777	O75558
PDB IDs		2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle	Neurotransmitter Secretion Glutamate Secretion Vesicle Localization Regulation Of Neurotransmitter Levels Neurotransmitter Transport Gene Expression Organelle Localization Synaptic Vesicle Transport Establishment Of Vesicle Localization Establishment Of Organelle Localization Vesicle Organization Synaptic Vesicle Exocytosis Acid Secretion Energy Reserve Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Dicarboxylic Acid Transport Organelle Organization Membrane Docking Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Exocytosis RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Secretion By Cell Regulation Of RNA Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Viral Process Synaptic Vesicle Docking Membrane Fusion Axon Cargo Transport Synaptic Vesicle Priming Regulation Of Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Vesicle Fusion Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Generation Of Precursor Metabolites And Energy Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Macromolecule Biosynthetic Process Cellular Localization
Tagcloud ?		assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus	autosomal characterised defect done dysregulation familial families fhl haemophagocytic harbour harbouring killer leukaemia lymphohistiocytosis milder mutational myelogenous nonsense perforin periods prf1 psychomotor recessive retardation segregation syntaxin uncommon undertaken unrelated
Tagcloud (Difference) ?		assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted sixteen soon spite vertebrate w xenopus	autosomal characterised defect done dysregulation familial families fhl haemophagocytic harbour harbouring killer leukaemia lymphohistiocytosis milder mutational myelogenous nonsense perforin periods prf1 psychomotor recessive retardation syntaxin uncommon undertaken unrelated
Tagcloud (Intersection) ?		segregation