NDC80 and ZWINT

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		NDC80	ZWINT
Description		NDC80 kinetochore complex component	ZW10 interacting kinetochore protein
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Membrane Nuclear Speck Ndc80 Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Dendrite Knl1/Spc105 Complex
	Molecular Function	Protein Binding Microtubule Binding Cyclin Binding Identical Protein Binding Kinetochore Adaptor Activity	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling G2/MI Transition Of Meiotic Cell Cycle Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Chromosome Organization Centrosome Duplication Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nuclear Chromosome Segregation	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Homologous Chromosome Orientation In Meiotic Metaphase I Cell Division Establishment Of Localization In Cell Regulation Of Meiosis I Spindle Assembly Checkpoint
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Cardiac hypertrophy ( 21348951) Cognitive function in longevity ( 33607172) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)
Interacting Genes		57 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CEP63 CIP2A CKAP5 EXOC8 GOLGA2 HAUS1 HGS IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 SFR1 SKA1 SKA3 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT	17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10
Entrez ID		10403	11130
HPRD ID		06277	18366
Ensembl ID		ENSG00000080986	ENSG00000122952
Uniprot IDs		A8K031 O14777	O95229
PDB IDs		2IGP 2VE7 3IZ0 8G0P	8PPR
Enriched GO Terms of Interacting Partners?		Kinetochore Cell Division Chromosome, Centromeric Region Organelle Organization Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Centrosome Regulation Of Chromosome Separation Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Microtubule-based Process Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Mitotic Sister Chromatid Segregation Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Sister Chromatid Segregation Regulation Of Sister Chromatid Segregation Spindle Pole Cytoskeleton Organization Regulation Of Chromosome Segregation Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Spindle Regulation Of Chromosome Organization Positive Regulation Of Mitotic Sister Chromatid Separation Organelle Assembly Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Process Microtubule Chromosome Organization Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cell Cycle	Outer Kinetochore Positive Regulation Of Amyloid Fibril Formation Cell Division Mitotic Sister Chromatid Segregation Chromosome Segregation Sister Chromatid Segregation Skeletal Muscle Satellite Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore MIS12/MIND Type Complex Chromosome, Centromeric Region Nuclear Chromosome Segregation Kinetochore Organelle Organization Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell Intracellular Transport Segment Specification Kinetochore Organization Regulation Of Amyloid Fibril Formation Regulation Of Amyloid-beta Clearance Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Chromosome Organization Cellular Localization Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Protein Transport Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Spindle Pole Mitotic Cell Cycle Positive Regulation Of Endocytosis Establishment Of Mitotic Spindle Orientation Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Developmental Process Positive Regulation Of Nitric Oxide Metabolic Process Establishment Of Mitotic Spindle Localization Negative Regulation Of Mitotic Nuclear Division Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Establishment Of Integrated Proviral Latency T Cell Differentiation In Thymus Establishment Of Spindle Orientation
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