NDC80 and MIS12

Number of citations of the paper that reports this interaction (PMID 15502821)
80

Data Source:
HPRD (in vivo, in vitro)

		NDC80	MIS12
Gene Name		NDC80 kinetochore complex component	MIS12 kinetochore complex component
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex	MIS12/MIND Type Complex Nucleus Cytosol
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division Kinetochore Assembly
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT	10 interactors: CASC5 CBX3 CBX5 DSN1 HSP90AA1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		10403	79003
HPRD ID		06277	12379
Ensembl ID		ENSG00000080986	ENSG00000167842
Uniprot IDs		A8K031 O14777	A8K1M4 Q9H081
PDB IDs		2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle	Mitotic Nuclear Division Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Cell Cycle Cell Division Organelle Organization Attachment Of Spindle Microtubules To Kinetochore Chromosome Organization Microtubule Anchoring Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Maintenance Of Protein Location In Cell Protein Import Into Mitochondrial Outer Membrane Chromatin Modification Maintenance Of Protein Location Maintenance Of Location In Cell Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Remodeling Chromatin Organization Protein Localization To Kinetochore Cell Cycle Checkpoint Protein Localization To Chromosome, Centromeric Region Histone H4-K5 Acetylation Histone H4-K8 Acetylation Chaperone-mediated Protein Complex Assembly Histone H4-K16 Acetylation Acrosome Assembly
Tagcloud ?		assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus