NDC80 and MIS12

Number of citations of the paper that reports this interaction (PubMedID 15502821)
0

Data Source:
HPRD (in vitro, in vivo)

		NDC80	MIS12
Description		NDC80 kinetochore complex component	MIS12 kinetochore complex component
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Membrane Nuclear Speck Ndc80 Complex	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytosol
	Molecular Function	Protein Binding Microtubule Binding Cyclin Binding Identical Protein Binding Kinetochore Adaptor Activity	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling G2/MI Transition Of Meiotic Cell Cycle Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Chromosome Organization Centrosome Duplication Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nuclear Chromosome Segregation	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		57 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CEP63 CIP2A CKAP5 EXOC8 GOLGA2 HAUS1 HGS IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 SFR1 SKA1 SKA3 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT	9 interacting genes: CBX3 CBX5 DSN1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		10403	79003
HPRD ID		06277	12379
Ensembl ID		ENSG00000080986	ENSG00000167842
Uniprot IDs		A8K031 O14777	A8K1M4 Q9H081
PDB IDs		2IGP 2VE7 3IZ0 8G0P	5LSJ 5LSK 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Kinetochore Cell Division Chromosome, Centromeric Region Organelle Organization Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Centrosome Regulation Of Chromosome Separation Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Microtubule-based Process Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Mitotic Sister Chromatid Segregation Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Sister Chromatid Segregation Regulation Of Sister Chromatid Segregation Spindle Pole Cytoskeleton Organization Regulation Of Chromosome Segregation Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Spindle Regulation Of Chromosome Organization Positive Regulation Of Mitotic Sister Chromatid Separation Organelle Assembly Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Process Microtubule Chromosome Organization Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cell Cycle	Outer Kinetochore Chromosome, Centromeric Region Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation MIS12/MIND Type Complex Skeletal Muscle Satellite Cell Proliferation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Skeletal Muscle Cell Proliferation Nuclear Chromosome Segregation Chromosome Cell Division Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Nuclear Body Muscle Cell Proliferation Regulation Of Meiosis I Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Chromosome Localization Nucleus Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Kinetochore Organization Positive Regulation Of Cell Cycle Checkpoint Nucleoplasm Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Pole Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Pericentric Heterochromatin Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Nuclear Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Nuclear Division Site Of DNA Damage Regulation Of Chromosome Organization Heterochromatin Positive Regulation Of Cell Cycle Process Regulation Of TRNA Methylation Kinetochore Adaptor Activity Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Regulation Of Meiotic Cell Cycle
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