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TRIM46 and UCHL5
Number of citations of the paper that reports this interaction (PMID
23105109
)
4
Data Source:
BioGRID
(two hybrid)
TRIM46
UCHL5
Gene Name
tripartite motif containing 46
ubiquitin carboxyl-terminal hydrolase L5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Proteasome Complex
Nucleus
Cytosol
Ino80 Complex
Molecular Function
Zinc Ion Binding
Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Omega Peptidase Activity
Poly(A) RNA Binding
Proteasome Binding
Biological Process
DNA Repair
DNA Recombination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Lateral Ventricle Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Forebrain Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Pathways
Interferon gamma signaling
Interferon Signaling
Cytokine Signaling in Immune system
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Urate levels (
23263486
)
Cannabis dependence (
21668797
)
Protein-Protein Interactions
17 interactors:
AK5
BRCA1
CBLC
MDM4
OTUD6A
RNF125
RNF7
TK1
TRIM9
TSG101
UBE2U
UBE2Z
UCHL5
USP1
USP15
USP2
USP32
96 interactors:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
HAUS7
HBA1
HBA2
HBB
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBE3A
USP28
YWHAZ
ZBED1
Entrez ID
80128
51377
HPRD ID
15563
10293
Ensembl ID
ENSG00000163462
ENSG00000116750
Uniprot IDs
B7Z3S2
B7Z4F9
F5GYK0
Q7Z4K8
Q9Y5K5
PDB IDs
3A7S
3IHR
3RII
3RIS
3TB3
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Protein Deubiquitination
Protein Modification By Small Protein Removal
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Metabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Protein Metabolic Process
Catabolic Process
Cellular Metabolic Process
Monoubiquitinated Protein Deubiquitination
Regulation Of Protein Metabolic Process
Regulation Of Proteolysis
Cellular Response To DNA Damage Stimulus
Regulation Of Cellular Protein Metabolic Process
Protein Polyubiquitination
Cellular Response To Stress
DNA Metabolic Process
DNA Repair
Positive Regulation Of Histone H4-K20 Methylation
Fetal Process Involved In Parturition
DADP Biosynthetic Process
Positive Regulation Of Histone H4-K16 Acetylation
Regulation Of DNA Repair
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Metabolic Process
G0 To G1 Transition
Skeletal Muscle Cell Proliferation
Positive Regulation Of Histone H3-K9 Acetylation
Histone H2B Conserved C-terminal Lysine Deubiquitination
Protein K27-linked Deubiquitination
Negative Regulation Of SNARE Complex Assembly
DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Stabilization
Signal Transduction In Response To DNA Damage
Regulation Of Cell Cycle Arrest
Positive Regulation Of Histone H4 Acetylation
Negative Regulation Of Histone H3-K4 Methylation
Protein K33-linked Deubiquitination
Protein K29-linked Deubiquitination
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
Regulation Of Megakaryocyte Differentiation
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
CENP-A Containing Nucleosome Assembly
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Demethylation
Centromere Complex Assembly
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Gene Silencing
DNA Methylation
Nucleosome Organization
Nucleosome Assembly
Chromatin Assembly
Telomere Maintenance
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Protein Complex Assembly
Regulation Of Gene Expression, Epigenetic
DNA Packaging
Cellular Component Assembly
Regulation Of Myeloid Cell Differentiation
DNA Conformation Change
Chromatin Remodeling
Negative Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Cellular Macromolecular Complex Assembly
Negative Regulation Of Cell Differentiation
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Immune System Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Modification
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Cellular Protein Metabolic Process
Homeostatic Process
Tagcloud
?
a1cf
activins
acvr1b
acvrl1
ancestry
atxn2
b3gnt4
baz1b
consortium
excretion
fractional
gout
gugc
hlf
hnf4g
implicate
inhbb
inhibins
maf
nfat5
painful
prkag2
replicated
sfmbt1
stc1
tmem171
ube2q2
urate
vegfa
Tagcloud (Difference)
?
a1cf
activins
acvr1b
acvrl1
ancestry
atxn2
b3gnt4
baz1b
consortium
excretion
fractional
gout
gugc
hlf
hnf4g
implicate
inhbb
inhibins
maf
nfat5
painful
prkag2
replicated
sfmbt1
stc1
tmem171
ube2q2
urate
vegfa
Tagcloud (Intersection)
?