TRIM46 and USP1

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		TRIM46	USP1
Gene Name		tripartite motif containing 46	ubiquitin specific peptidase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Nucleus Nucleoplasm
	Molecular Function	Zinc Ion Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding
	Biological Process		Skeletal System Development DNA Repair Regulation Of DNA Repair Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Fanconi Anemia pathway Regulation of the Fanconi anemia pathway
Drugs
Diseases
GWAS		Urate levels ( 23263486)
Protein-Protein Interactions		17 interactors: AK5 BRCA1 CBLC MDM4 OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32	9 interactors: DTX3 FANCD2 PCNA PHF7 PHLPP1 TRAF6 TRIM46 UBB UBC
Entrez ID		80128	7398
HPRD ID		15563	04593
Ensembl ID		ENSG00000163462	ENSG00000162607
Uniprot IDs		B7Z3S2 B7Z4F9 F5GYK0 Q7Z4K8	O94782
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Catabolic Process Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cellular Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Cellular Response To Stress DNA Metabolic Process DNA Repair Positive Regulation Of Histone H4-K20 Methylation Fetal Process Involved In Parturition DADP Biosynthetic Process Positive Regulation Of Histone H4-K16 Acetylation Regulation Of DNA Repair Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Metabolic Process G0 To G1 Transition Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Protein K27-linked Deubiquitination Negative Regulation Of SNARE Complex Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Stabilization Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Arrest Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination	Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Fc Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Viral Protein Processing Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-regulating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Notch Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Protein Ubiquitination Cellular Response To Growth Factor Stimulus Protein Polyubiquitination DNA Repair Response To Growth Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Modification By Small Protein Conjugation Positive Regulation Of Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Notch Receptor Processing Response To Fibroblast Growth Factor Virion Assembly
Tagcloud ?		a1cf activins acvr1b acvrl1 ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 ube2q2 urate vegfa	bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih hif1an interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp9 zebrafish zranb1
Tagcloud (Difference) ?		a1cf activins acvr1b acvrl1 ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 ube2q2 urate vegfa	bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih hif1an interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp9 zebrafish zranb1
Tagcloud (Intersection) ?