SLC22A3 and PDZD3

Number of citations of the paper that reports this interaction (PMID 15553237)
5

Data Source:
HPRD (two hybrid)

		SLC22A3	PDZD3
Gene Name		solute carrier family 22 (organic cation transporter), member 3	PDZ domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Cytosol Brush Border Subapical Complex Apical Part Of Cell
	Molecular Function	Dopamine Transmembrane Transporter Activity Protein Binding Organic Cation Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transporter Activity	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity
	Biological Process	Drug Transmembrane Transport Organic Cation Transport Quaternary Ammonium Group Transport Dopamine Transport Regulation Of Appetite Small Molecule Metabolic Process Histamine Uptake Transmembrane Transport Ammonium Transmembrane Transport Toxin Transport	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance CGMP-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity
Pathways		Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Abacavir transmembrane transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport Abacavir transport and metabolism
Drugs
Diseases
GWAS		Colorectal cancer ( 21242260) Coronary heart disease ( 19198611) Lp (a) levels ( 21900290) Prostate cancer ( 18264097) Response to hepatitis C treatment ( 22095909)
Protein-Protein Interactions		1 interactors: PDZD3	17 interactors: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		6581	79849
HPRD ID		05328	06191
Ensembl ID		ENSG00000146477	ENSG00000172367
Uniprot IDs		O75751	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Regulation Of CGMP Biosynthetic Process Negative Regulation Of Lyase Activity Cyclic-nucleotide-mediated Signaling Regulation Of CGMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Water Transport Fluid Transport Regulation Of Cyclase Activity Second-messenger-mediated Signaling Response To Toxic Substance	Transmembrane Transport Ion Transport Ion Transmembrane Transport Sodium-independent Organic Anion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Drug Transport Monocarboxylic Acid Transport Quaternary Ammonium Group Transport Transport Cation Transmembrane Transport Drug Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Antibiotic Transport Toxin Transport Ammonium Transmembrane Transport Organic Cation Transport Cation Transport Oligopeptide Transport Ammonium Transport Response To Drug Inorganic Anion Transport Carnitine Transmembrane Transport Carnitine Transport Lipid Transport Lipid Localization Monovalent Inorganic Cation Transport Dipeptide Transport Histamine Uptake Positive Regulation Of ARF GTPase Activity Short-chain Fatty Acid Import Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Intestinal Epithelial Structure Maintenance Quorum Sensing Involved In Interaction With Host Sodium-dependent Organic Cation Transport Fatty Acid Transport Regulation Of Intestinal Epithelial Structure Maintenance Prostaglandin Transport Peptide Transport Hormone Transport Extraocular Skeletal Muscle Development Oligopeptide Transmembrane Transport Regulation Of Chloride Transport Amide Transport Iodide Transport Thyroid Hormone Transport Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis
Tagcloud ?		anat asmt characterise circumventricular cldn3 col11a1 cvos epcam ependyma ependymocytes lcm microdissection organum ovlt peculiar periventricular pineal ren1 sco sfo specialised subcommissural subfornical terminalis tph transcriptomes vasculosum ventricles vestigial
Tagcloud (Difference) ?		anat asmt characterise circumventricular cldn3 col11a1 cvos epcam ependyma ependymocytes lcm microdissection organum ovlt peculiar periventricular pineal ren1 sco sfo specialised subcommissural subfornical terminalis tph transcriptomes vasculosum ventricles vestigial
Tagcloud (Intersection) ?