SLCO1A2

Description		solute carrier organic anion transporter family member 1A2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Xenobiotic Metabolic Process Monoatomic Ion Transport Lipid Transport Organic Cation Transport Organic Anion Transport Bile Acid And Bile Salt Transport Sodium-independent Organic Anion Transport Transmembrane Transport
Pathways		Recycling of bile acids and salts Organic anion transport by SLCO transporters Ciprofloxacin ADME
Drugs
Diseases
GWAS		AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Bilirubin levels ( 19414484) Diisocyanate-induced asthma ( 25918132) Methotrexate pharmacokinetics (acute lymphoblastic leukemia) ( 19901119) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Progressive supranuclear palsy ( 21685912 30089514) Rocuronium dose requirement in breast cancer surgery ( 33676726) Serum metabolite levels ( 23093944) Statin-induced myopathy (severe) ( 31220337)
Interacting Genes		4 interacting genes: NHERF1 NHERF2 NHERF4 PDZK1
Entrez ID		6579
HPRD ID		09112
Ensembl ID		ENSG00000084453
Uniprot IDs		B4DJE6 P46721
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Type 3 Metabotropic Glutamate Receptor Binding Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Cellular Localization Brush Border Membrane Phosphatase Binding Brush Border Intracellular Protein Localization PDZ Domain Binding Apical Part Of Cell Beta-catenin Binding Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Molecular Adaptor Activity Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Endomembrane System Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Quaternary Ammonium Group Transport
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