ASAP3 and TEPSIN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASAP3	TEPSIN
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	TEPSIN adaptor related protein complex 4 accessory protein
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Cytosol Focal Adhesion Intracellular Membrane-bounded Organelle	Cytoplasm Golgi Apparatus Cytosol Membrane Coated Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	Cell Migration Positive Regulation Of GTPase Activity Regulation Of Stress Fiber Assembly
Pathways
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Severe insulin-resistant type 2 diabetes ( 34737425) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549)	IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391)
Interacting Genes		9 interacting genes: ARF6 CRK MTNR1A NHERF4 REL TCF4 TEPSIN TFCP2 UBE3A	126 interacting genes: AATK ACBD7 AGRN AIRIM AP1M1 APOL6 APP ASAP3 ASB3 ATOSB BCL2L14 BCL2L15 BIRC7 BPIFA1 BTBD3 C1QTNF4 CBX8 CCDC146 CCNC CDC23 CINP CLCNKA CLIC3 CNTF CPNE7 CSNK2A1 CTAG1A CTAG1B CYSRT1 DEF6 DUSP29 DUSP4 DZIP1L EIF1AD FAM90A1 FARS2 FKBP6 FLACC1 FNDC3B GNG13 GOLGA2 GPANK1 GPRASP3 GRB10 GRIPAP1 GUCD1 HAT1 HCK HPCA HSF2BP HSPB7 IL16 IQGAP1 KCTD6 KCTD9 KHNYN KLHL38 KRT31 KRT34 KRT35 KRTAP6-2 LENG1 LGALS14 LMO3 LSM3 LYG2 MAT2B MED18 MFAP1 MLX MORF4L1 MSGN1 MTUS2 NDOR1 NEK6 NGB NME7 NR2C2AP NTAQ1 NUDT14 NUDT21 OAZ3 OR6B1 PAX9 PCDHB3 PLEKHA2 PSMA6 RAB3IP RAD51D RANBP3 RNF135 SEC14L4 SLU7 SNRNP25 SORBS2 SORBS3 SZT2 TAPBPL TBC1D13 TBC1D22B TCEA2 TCL1A TFAP2D THRSP TRAPPC2 TRAPPC2B TRAPPC6A TRIM23 TRIM45 TRIM50 TRIM54 TRIM68 TSEN15 TSEN2 TSHZ3 TSSK3 UBASH3B UTP23 VPS26C WDR25 YPEL3 ZIC1 ZMYND12 ZNF343 ZNF629 ZRSR2
Entrez ID		55616	146705
HPRD ID		11662	08103
Ensembl ID		ENSG00000088280	ENSG00000167302
Uniprot IDs		A0AAA9YHE6 B4DRP2 Q8TDY4	A0A1B0GV70 Q96N21
PDB IDs		2B0O 3LVQ 3LVR	5WF9 5WFB
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Postsynaptic Specialization Organization Regulation Of Rac Protein Signal Transduction Erythrocyte Apoptotic Process Protein Localization To Membrane Cellular Response To Nerve Growth Factor Stimulus Sperm Entry Positive Regulation Of Golgi Lumen Acidification Guanylate Cyclase Inhibitor Activity Coated Vesicle Membrane Signaling Adaptor Activity Positive Regulation Of Protein Localization To Membrane Establishment Of Cell Polarity Regulation Of Dendrite Development Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Protein Localization Protein Localization To Cleavage Furrow Cerebellar Neuron Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Beta-catenin-TCF7L2 Complex Regulation Of Golgi Lumen Acidification Regulation Of Intracellular Signal Transduction Localization Within Membrane Melatonin Receptor Activity NF-kappaB Complex TFIIB-class Transcription Factor Binding	Protein Binding Nucleus Identical Protein Binding TRAPPIII Protein Complex
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