VPS37B and SORBS3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VPS37B	SORBS3
Gene Name		vacuolar protein sorting 37 homolog B (S. cerevisiae)	sorbin and SH3 domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	ESCRT I Complex Endosome Membrane Midbody Late Endosome Membrane Extracellular Vesicular Exosome	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Membrane Organization Intracellular Transport Of Virus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle	Smooth Muscle Contraction
Drugs
Diseases
GWAS			HIV-1 control ( 20205591)
Protein-Protein Interactions		15 interactors: AES BYSL CDC73 DCUN1D1 ERCC1 FBF1 NCK2 PRKAA1 QARS SH3YL1 SMARCD1 SORBS3 TSG101 UBASH3B VPS28	46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		79720	10174
HPRD ID		07794	11535
Ensembl ID		ENSG00000139722	ENSG00000120896
Uniprot IDs		Q9H9H4	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Viral Protein Processing Virion Assembly Negative Regulation Of Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Of Virus Organelle Organization Wnt Signaling Pathway Glutaminyl-tRNA Aminoacylation Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Anatomical Structure Development Negative Regulation Of Gene Expression Regulation Of Metabolic Process Prolyl-tRNA Aminoacylation Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Post-embryonic Hemopoiesis Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Glucose Import In Response To Insulin Stimulus Regulation Of Organelle Organization Developmental Process Anatomical Structure Morphogenesis Response To Camptothecin Glutamyl-tRNA Aminoacylation Positive Regulation Of Anoikis Pyrimidine Dimer Repair By Nucleotide-excision Repair Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Response To Extracellular Stimulus Chromosome Organization Response To UV Anatomical Structure Formation Involved In Morphogenesis Response To Ionizing Radiation Regulation Of Extracellular Vesicular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Sphingolipid Biosynthetic Process Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated Response To External Stimulus Multicellular Organismal Development Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide-excision Repair, DNA Incision Late Endosome To Vacuole Transport Replicative Cell Aging Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process
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