SCNM1 and TRIM37

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SCNM1	TRIM37
Gene Name		sodium channel modifier 1	tripartite motif containing 37
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Nuclear Speck	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Enzyme Binding Metal Ion Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	MRNA Processing RNA Splicing	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		43 interactors: AES BLZF1 CCDC33 CCDC85B CDR2 CEP44 GOLGA2 HMG20A IKZF1 INCA1 KRT31 KRT38 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 LZTS2 MCM6 MEOX2 MID2 MIPOL1 MKRN3 NAB2 NOTCH2NL PDE4DIP PLSCR1 PNMA1 PNMA2 PRNP RINT1 RPGRIP1 SPERT SSX2IP SYCE1 TRAF1 TRIM27 TRIM37 TRIM42 TRIM54 UBXN11 ZBTB14 ZDHHC17	59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655
Entrez ID		79005	4591
HPRD ID		12162	05463
Ensembl ID		ENSG00000163156	ENSG00000108395
Uniprot IDs		Q9BWG6	A8K0V9 A8K8U4 F8WEE6 O94972
PDB IDs			3LRQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Viral Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Cell Cycle Negative Regulation Of Interleukin-2 Production Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Viral Transcription Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Release From Host Cell Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Viral Process Positive Regulation Of Neutrophil Differentiation Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Transcription, DNA-templated Cellular Component Assembly RNA Biosynthetic Process Negative Regulation Of Protein Binding Negative Regulation Of Interleukin-2 Secretion Cellular Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Viral Transcription Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Histone H2A-K119 Monoubiquitination Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Anoikis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Growth Negative Regulation Of Protein Phosphorylation Negative Regulation Of Binding Positive Regulation Of Cell Death Intraciliary Transport Involved In Cilium Morphogenesis	Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process
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