SCNM1 and PRR5L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCNM1	PRR5L
Description		sodium channel modifier 1	proline rich 5 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	TORC2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Migration Cellular Response To Oxidative Stress TORC2 Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Intracellular Protein Transport
Pathways
Drugs
Diseases
GWAS			A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059 31619474 31361310 30929738) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 23727859 26482879) Hip index ( 34021172) Idiopathic inflammatory myopathy ( 26362759) Inflammatory skin disease ( 25574825) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244 24076602) Photic sneeze reflex ( 27182965) Red blood cell count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		179 interacting genes: ADAMTSL4 AKAP9 AVPI1 AXIN2 BACH2 BEND7 BLZF1 CALCOCO2 CARD10 CARD9 CBY2 CCDC136 CCDC28B CCDC33 CCDC74B CCDC85B CDR2 CDR2L CEP44 CEP70 CEP76 CHIC2 CIB3 COG6 CTDSP1 CYSRT1 CYTIP DRC4 DVL2 EZHIP FAM161A FAM228A FANCL FHL2 FHL5 FNDC11 FRS3 FSD2 GIGYF1 GOLGA2 GOLGA6L9 GPRASP3 HAP1 HMBOX1 HMG20A HOMER3 HOMEZ HOOK2 HSF2BP IKZF1 IKZF3 INCA1 IRAK1BP1 JAKMIP1 KANK2 KATNBL1 KIFC3 KLF15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT39 KRT40 KRT75 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP5-9 LCN2 LDOC1 LHX1 LHX3 LIMS1 LNX1 LNX2 LRP2BP LZTS1 LZTS2 MCM6 MDFI MEOX2 MID2 MIPOL1 MKRN3 MORN3 MRPL28 MSS51 MTUS2 MYLIP MYO1F NAB2 NAP1L2 NBPF19 NDUFB7 NFKBID NOTCH2NLA NUTM1 PBX4 PDE4DIP PDLIM7 PFDN5 PIBF1 PICK1 PIH1D1 PLSCR1 PNMA1 PNMA2 PPP1R16A PPP1R16B PRDM14 PRNP PRR5L PSTPIP1 RBAK RBM11 RBM48 RDM1 REL RHOH RINT1 RORB RPGRIP1 RPH3AL SMARCD1 SORBS3 SSX2IP STX11 STX19 SYCE1 TAX1BP1 TFIP11 TLE5 TNNI1 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM23 TRIM27 TRIM37 TRIM42 TRIM54 TTC23L UBXN11 USH1G USHBP1 VIM VMAC VPS52 VWC2 ZBTB1 ZBTB14 ZDHHC17 ZGPAT ZIM2 ZMAT1 ZMYND12 ZNF135 ZNF19 ZNF20 ZNF202 ZNF438 ZNF511 ZNF526 ZNF547 ZNF552 ZNF641 ZNF688 ZNF76 ZNF774 ZNF829 ZRANB1	15 interacting genes: CCDC91 EFHC1 FHL2 FHL3 HSF2BP KANK2 MAD2L2 MISP MLH1 MORN3 MTOR PHAF1 SCNM1 USP2 ZMYND12
Entrez ID		79005	79899
HPRD ID		12162	07854
Ensembl ID		ENSG00000163156	ENSG00000135362
Uniprot IDs		Q9BWG6	B3KNU3 Q6MZQ0
PDB IDs		7DVQ 8Y7E
Enriched GO Terms of Interacting Partners?		Protein Binding Keratin Filament Intermediate Filament Zinc Ion Binding Intermediate Filament Organization Structural Constituent Of Skin Epidermis Identical Protein Binding Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Microtubule Binding Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Supramolecular Fiber Organization Centrosome TORC1 Complex Assembly Structural Molecule Activity Regulation Of Transcription By RNA Polymerase II DNA Binding Cytoskeleton Organization Ubiquitin Protein Ligase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcium-mediated Signaling Regulation Of Signal Transduction By P53 Class Mediator Cardiac Cell Development Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Cardiac Muscle Cell Development Organelle Organization Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Double-strand Break Repair Male Meiotic Nuclear Division Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response Late Recombination Nodule Somatic Diversification Of Immunoglobulins Meiotic Metaphase I Homologous Chromosome Alignment DNA Damage Response, Signal Transduction Resulting In Transcription Cytoskeleton Organization Positive Regulation Of Immunoglobulin Production Atrial Cardiac Muscle Cell Development Regulation Of Locomotor Rhythm TFIIIC-class Transcription Factor Complex Binding Meiotic Spindle Midzone Assembly Meiosis I Cell Cycle Process Meiotic Metaphase Chromosome Alignment Chiasma Negative Regulation Of Vitamin D Receptor Signaling Pathway Striated Muscle Cell Development Meiotic Nuclear Division Positive Regulation Of DNA Recombination
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