SCNM1 and LHX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCNM1	LHX1
Description		sodium channel modifier 1	LIM homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Urogenital System Development Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Gastrulation With Mouth Forming Second Ectoderm Formation Endoderm Formation Kidney Development Mesonephros Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Pattern Specification Process Nervous System Development Endoderm Development Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Post-embryonic Development Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Regulation Of Gene Expression Retina Layer Formation Spinal Cord Development Ventral Spinal Cord Development Spinal Cord Association Neuron Differentiation Telencephalon Development Cerebellum Development Cerebellar Purkinje Cell Differentiation Forebrain Regionalization Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Cell Differentiation Neuron Differentiation Somite Rostral/caudal Axis Specification Metanephric Part Of Ureteric Bud Development Oviduct Epithelium Development Uterine Epithelium Development Nephric Duct Elongation Positive Regulation Of Embryonic Development Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesendoderm Development Anatomical Structure Formation Involved In Morphogenesis Embryonic Viscerocranium Morphogenesis System Development Pronephros Development Retina Development In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Oviduct Development Cervix Development Vagina Development Head Development Epithelium Development Paramesonephric Duct Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Vesicle Morphogenesis Mesonephric Tubule Development Mesonephric Duct Development Nephric Duct Morphogenesis Ureter Morphogenesis Metanephric Glomerulus Development Metanephric Comma-shaped Body Morphogenesis Metanephric Renal Vesicle Morphogenesis Metanephric S-shaped Body Morphogenesis Primitive Streak Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Dorsal Spinal Cord Interneuron Posterior Axon Guidance Lateral Motor Column Neuron Migration Positive Regulation Of Gastrulation Positive Regulation Of Anterior Head Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation
Pathways			Formation of intermediate mesoderm Formation of the nephric duct Nephron development
Drugs
Diseases
GWAS			Alzheimer's disease ( 30636644) Body mass index ( 26426971) Carotid intima media thickness x smoking interaction ( 32117412) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		179 interacting genes: ADAMTSL4 AKAP9 AVPI1 AXIN2 BACH2 BEND7 BLZF1 CALCOCO2 CARD10 CARD9 CBY2 CCDC136 CCDC28B CCDC33 CCDC74B CCDC85B CDR2 CDR2L CEP44 CEP70 CEP76 CHIC2 CIB3 COG6 CTDSP1 CYSRT1 CYTIP DRC4 DVL2 EZHIP FAM161A FAM228A FANCL FHL2 FHL5 FNDC11 FRS3 FSD2 GIGYF1 GOLGA2 GOLGA6L9 GPRASP3 HAP1 HMBOX1 HMG20A HOMER3 HOMEZ HOOK2 HSF2BP IKZF1 IKZF3 INCA1 IRAK1BP1 JAKMIP1 KANK2 KATNBL1 KIFC3 KLF15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT39 KRT40 KRT75 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP5-9 LCN2 LDOC1 LHX1 LHX3 LIMS1 LNX1 LNX2 LRP2BP LZTS1 LZTS2 MCM6 MDFI MEOX2 MID2 MIPOL1 MKRN3 MORN3 MRPL28 MSS51 MTUS2 MYLIP MYO1F NAB2 NAP1L2 NBPF19 NDUFB7 NFKBID NOTCH2NLA NUTM1 PBX4 PDE4DIP PDLIM7 PFDN5 PIBF1 PICK1 PIH1D1 PLSCR1 PNMA1 PNMA2 PPP1R16A PPP1R16B PRDM14 PRNP PRR5L PSTPIP1 RBAK RBM11 RBM48 RDM1 REL RHOH RINT1 RORB RPGRIP1 RPH3AL SMARCD1 SORBS3 SSX2IP STX11 STX19 SYCE1 TAX1BP1 TFIP11 TLE5 TNNI1 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM23 TRIM27 TRIM37 TRIM42 TRIM54 TTC23L UBXN11 USH1G USHBP1 VIM VMAC VPS52 VWC2 ZBTB1 ZBTB14 ZDHHC17 ZGPAT ZIM2 ZMAT1 ZMYND12 ZNF135 ZNF19 ZNF20 ZNF202 ZNF438 ZNF511 ZNF526 ZNF547 ZNF552 ZNF641 ZNF688 ZNF76 ZNF774 ZNF829 ZRANB1	9 interacting genes: CATSPERT FOXA2 ISL1 KANK2 LDB1 LHX3 OTX2 RLIM SCNM1
Entrez ID		79005	3975
HPRD ID		12162	09067
Ensembl ID		ENSG00000163156	ENSG00000273706
Uniprot IDs		Q9BWG6	P48742 Q58F18
PDB IDs		7DVQ 8Y7E
Enriched GO Terms of Interacting Partners?		Protein Binding Keratin Filament Intermediate Filament Zinc Ion Binding Intermediate Filament Organization Structural Constituent Of Skin Epidermis Identical Protein Binding Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Microtubule Binding Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Supramolecular Fiber Organization Centrosome TORC1 Complex Assembly Structural Molecule Activity Regulation Of Transcription By RNA Polymerase II DNA Binding Cytoskeleton Organization Ubiquitin Protein Ligase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Neuron Differentiation Positive Regulation Of Gastrulation RNA Polymerase II-specific DNA-binding Transcription Factor Binding LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Cell Fate Specification Primitive Streak Formation Regulation Of Gastrulation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Embryonic Development Central Nervous System Neuron Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Pituitary Gland Development Dopaminergic Neuron Differentiation Chromatin Regulation Of Intracellular Estrogen Receptor Signaling Pathway Neuron Projection Guidance Cell Differentiation In Spinal Cord Axon Guidance Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Developmental Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Embryonic Development Regulation Of Smoothened Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Regulation Of Myofibroblast Contraction Negative Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Developmental Process
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