IKZF1 and MORF4L1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		IKZF1	MORF4L1
Description		IKAROS family zinc finger 1	mortality factor 4 like 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol Protein-containing Complex	Nucleosome Nucleus Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex Sin3-type Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding	Chromatin Binding Protein Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Mesoderm Development Lymphocyte Differentiation Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088 29296818) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 23512250 25310577 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29296818 29632299) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Area under the curve of insulin levels ( 24699409) Aspartate aminotransferase levels ( 29403010) Asthma ( 32296059) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement ( 25672763) Crohn's disease ( 21102463) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 32203549) Height ( 28552196) Hemoglobin ( 32888494) Hemoglobin levels ( 28017375) hemolysis of donated blood (osmotic) ( 34014839) High density lipoprotein cholesterol levels ( 29403010 33339817) Hippocampal atrophy ( 19668339) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 33536631) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 19862010 27863252 28017375 28453575 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602) N-glycan levels ( 31163085) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 27863252 29403010 32888494) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Serum total protein levels ( 29403010) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 19838193 19838195 23273568 26502338 26663301 27399966 28714469) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 29403010 33339817) Type 1 diabetes ( 25751624)	Coronary artery disease ( 32469254 33020668) Coronary heart disease ( 21378988) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 31577861) Lung cancer in ever smokers ( 28604730) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		107 interacting genes: AEN AIRIM ALKBH3 ANKRD11 ANKRD36 AP1M1 AP2M1 ARMC7 ATOSB BARD1 BYSL C1orf174 C8orf33 CBX8 CCDC185 CDC7 CDK2AP2 CDKL3 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CWF19L2 DCX DDB1 DDX6 DYRK2 FAM161A FAM50B FAM74A4 FGF12 FHL2 FOXP1 FRMD6 GLRX3 GMCL2 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LHX4 LMO1 LMO2 LMO3 LMO4 LSM4 MAD2L2 MAGOHB MAPRE3 MCRS1 MEOX2 MORF4L1 MORF4L2 MOS MPPED2 NEK6 NME7 NOC4L NUDT21 PIAS2 PIN1 PNKP PPL PRKAA2 PRKAB2 PRPF18 PSMA1 PSMA4 QARS1 RAD51D RBBP8 RBM43 RNF4 RNF6 RUNX1 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SHFL SIN3A SIN3B SMARCA4 SNRPA1 SNRPF SNW1 SPATC1L SYT17 TBP TCEA2 TDG TSTD2 TXK UBE2I USP7 ZMAT2 ZNF417 ZNF580 ZNF581 ZNF587	83 interacting genes: APP ARID3A ARRDC3 BEND7 BEX5 BTG3 CALM1 CAMK2B CEBPA CEP57L1 CWC27 DMAP1 DRAP1 DSCR9 DYSF EP300 FAM13C FAM9B FBXO16 FHL3 FXR2 GMCL1 GOLGA2 GOLGA6A GSC2 H3-4 H3C1 HINFP HMBOX1 IKZF1 KPNA2 L3MBTL3 LHX2 LMNA LZTS2 MEOX1 MEOX2 MRFAP1 MRFAP1L1 MRGBP MRPL12 MSL1 NAB2 NAV2 NECAB1 NKD1 NMI PBXIP1 PCM1 PHF12 PIBF1 PICK1 PLEKHA3 PSMC1 RACGAP1 RB1 RCBTB2 REL SH3GLB2 SYN3 TEPSIN TEX11 TFCP2 THAP1 TLE5 TNIP1 TNNT1 TNNT2 TRIM41 TTC3 TULP3 UBP1 USO1 VPS26A ZBTB10 ZBTB26 ZBTB43 ZBTB8B ZBTB9 ZC3H7A ZNF276 ZNF438 ZNF449
Entrez ID		10320	10933
HPRD ID		04318	09532
Ensembl ID		ENSG00000185811	ENSG00000185787
Uniprot IDs		A0A2R8Y4D3 A0A2R8YFR0 A0A8V8TNQ0 C9JTB0 Q13422 R9R4D9	Q9UBU8
PDB IDs		6H0F 8D7Z 8D80 8RQC 8TNP 8TNQ 8TNR	2AQL 2EFI 2F5J 2F5K 2LKM 2N1D 6AGO 6INE 7S4A 8BPA 8C60
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein Binding Sin3-type Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Androgen Receptor Signaling Pathway Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process NuRD Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process PML Body Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Cell Fate Specification Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA Metabolic Process Nuclear Speck U2-type Precatalytic Spliceosome Chromatin Organization RNA Splicing Negative Regulation Of Metabolic Process Protein K6-linked Ubiquitination DNA Repair	Identical Protein Binding Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Spermatogonial Cell Division Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Rb-E2F Complex Somite Specification Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Coregulator Activity Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Corepressor Activity Troponin Complex Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Importin-alpha Family Protein Binding Regulation Of Protein Localization To Nucleus Positive Regulation Of Metabolic Process Regulation Of Skeletal Muscle Adaptation DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
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