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IKZF1 and CDK2AP2
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
IKZF1
CDK2AP2
Gene Name
IKAROS family zinc finger 1 (Ikaros)
cyclin-dependent kinase 2 associated protein 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Pericentric Heterochromatin
Cytoplasm
Protein Complex
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Sequence-specific DNA Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Natural Killer Cell Differentiation
Transcription, DNA-templated
Cell Cycle
Mesoderm Development
Chromatin Modification
B Cell Differentiation
T Cell Differentiation
Forebrain Development
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Neutrophil Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Lymph Node Development
Thymus Development
Peyer's Patch Development
Positive Regulation Of NK T Cell Differentiation
Retina Development In Camera-type Eye
Pathways
Drugs
Diseases
GWAS
Acute lymphoblastic leukemia (childhood) (
23512250
19684603
19684604
)
Crohn's disease (
21102463
)
Hippocampal atrophy (
19668339
)
IgG glycosylation (
23382691
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular volume (
19862010
)
Red blood cell traits (
23222517
)
Systemic lupus erythematosus (
23273568
19838193
)
Protein-Protein Interactions
75 interactors:
AEN
ALKBH3
ANKRD11
AP1M1
AP2M1
ARMC7
BYSL
C19orf66
C1orf109
C1orf174
C8orf33
CBX8
CDK2AP2
CEP57L1
CHD3
CKS1B
CSNK1G1
CTBP1
CTBP2
DCX
DDX6
DYRK2
FAM161A
FAM214B
FAM50B
FAM74A4
FGF12
FRMD6
GLRX3
GMCL1P1
GTF2B
HDAC1
HDAC2
IKZF2
IKZF3
IKZF4
IKZF5
ISCU
KIF9
LMO3
LSM4
MAD2L2
MCRS1
MORF4L1
MORF4L2
MTA1
NEK6
NOC4L
NUDT21
PIN1
PNKP
PRKAB2
PSMA1
PSMA4
RAD51D
RBBP8
RWDD2B
SAP18
SCNM1
SDCBP
SH2D4A
SIN3A
SIN3B
SMARCA4
SNRPF
SNW1
SPATC1L
SYT17
TBP
TDG
UBE2I
WTAP
ZMAT2
ZNF417
ZNF581
17 interactors:
A2M
APP
CDK2AP1
DBN1
EED
EEF1G
HSF4
IKZF1
MBTPS1
MRFAP1L1
PYCR1
RCC1
RPLP1
TRA2A
WARS
YIF1A
ZBTB48
Entrez ID
10320
10263
HPRD ID
04318
13242
Ensembl ID
ENSG00000185811
ENSG00000167797
Uniprot IDs
Q13422
O75956
Q6IAV4
PDB IDs
2M1L
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Gene Expression
Transcription, DNA-templated
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Response To DNA Damage Stimulus
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Chromatin Organization
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression, Epigenetic
Cellular Response To Stress
Negative Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Organelle Organization
Chromosome Organization
Chromatin Modification
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Viral Process
Negative Regulation Of Gene Expression
Histone Deacetylation
Protein Deacetylation
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Histone Modification
Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Transcription From RNA Polymerase II Promoter
DNA Repair
Regulation Of Cell Cycle
Signal Transduction By P53 Class Mediator
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
DNA Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Metabolic Process
Regulation Of Cell Cycle Phase Transition
RNA Splicing
Gene Expression
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Nuclease Activity
Positive Regulation Of Neutrophil Differentiation
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Protein Metabolic Process
Nucleobase-containing Compound Metabolic Process
Platelet Degranulation
Cellular Macromolecule Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Macromolecule Biosynthetic Process
Tryptophanyl-tRNA Aminoacylation
Synaptic Growth At Neuromuscular Junction
Negative Regulation Of Complement Activation, Lectin Pathway
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Endoplasmic Reticulum Unfolded Protein Response
Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Collateral Sprouting In Absence Of Injury
Cell Communication By Chemical Coupling
Regulation Of Multicellular Organism Growth
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
Cellular Response To Topologically Incorrect Protein
Positive Regulation Of Protein Modification Process
Cholesterol Metabolic Process
Collateral Sprouting
Axon Midline Choice Point Recognition
L-proline Biosynthetic Process
Sterol Metabolic Process
Response To Unfolded Protein
Cellular Protein Metabolic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Hydrolase Activity
Protein Metabolic Process
Axon Choice Point Recognition
Positive Regulation Of NK T Cell Differentiation
Regulation Of Protein Phosphorylation
MRNA Metabolic Process
Histone H3-K9 Demethylation
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Ran GTPase Activity
Positive Regulation Of Granulocyte Differentiation
Tagcloud
?
agree
china
cnki
cochrane
databases
deletion
derive
efs
eligible
embase
estimation
ethnicity
hazard
infrastructure
intervals
lymphoblastic
meta
methodology
precise
pubmed
random
ratios
science
stratified
subgroups
unfavorable
updated
wanfang
web
Tagcloud (Difference)
?
agree
china
cnki
cochrane
databases
deletion
derive
efs
eligible
embase
estimation
ethnicity
hazard
infrastructure
intervals
lymphoblastic
meta
methodology
precise
pubmed
random
ratios
science
stratified
subgroups
unfavorable
updated
wanfang
web
Tagcloud (Intersection)
?