IKZF1 and RAD51D

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		IKZF1	RAD51D
Gene Name		IKAROS family zinc finger 1 (Ikaros)	RAD51 paralog D
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Pericentric Heterochromatin Cytoplasm Protein Complex	Chromosome, Telomeric Region Nucleus Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity	Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Gamma-tubulin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Natural Killer Cell Differentiation Transcription, DNA-templated Cell Cycle Mesoderm Development Chromatin Modification B Cell Differentiation T Cell Differentiation Forebrain Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Thymus Development Peyer's Patch Development Positive Regulation Of NK T Cell Differentiation Retina Development In Camera-type Eye	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Reciprocal Meiotic Recombination Strand Invasion
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23512250 19684603 19684604) Crohn's disease ( 21102463) Hippocampal atrophy ( 19668339) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 19838193)
Protein-Protein Interactions		75 interactors: AEN ALKBH3 ANKRD11 AP1M1 AP2M1 ARMC7 BYSL C19orf66 C1orf109 C1orf174 C8orf33 CBX8 CDK2AP2 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CTBP2 DCX DDX6 DYRK2 FAM161A FAM214B FAM50B FAM74A4 FGF12 FRMD6 GLRX3 GMCL1P1 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LMO3 LSM4 MAD2L2 MCRS1 MORF4L1 MORF4L2 MTA1 NEK6 NOC4L NUDT21 PIN1 PNKP PRKAB2 PSMA1 PSMA4 RAD51D RBBP8 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SIN3A SIN3B SMARCA4 SNRPF SNW1 SPATC1L SYT17 TBP TDG UBE2I WTAP ZMAT2 ZNF417 ZNF581	17 interactors: AMOTL2 BLM C1orf94 CEP57L1 IKZF1 IKZF3 KIFC3 KRT15 LNX1 LZTS2 PRDM14 RAD51B RAD51C SWSAP1 XRCC2 XRCC3 ZSWIM7
Entrez ID		10320	5892
HPRD ID		04318	04261
Ensembl ID		ENSG00000185811	ENSG00000185379
Uniprot IDs		Q13422	O75771
PDB IDs			2KZ3
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Organelle Organization Chromosome Organization Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Negative Regulation Of Gene Expression Histone Deacetylation Protein Deacetylation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Repair Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway DNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Metabolic Process Regulation Of Cell Cycle Phase Transition RNA Splicing	Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Organelle Organization Positive Regulation Of Mitotic Cell Cycle DNA Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle Nucleobase-containing Compound Metabolic Process Meiotic Nuclear Division Response To X-ray Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Meiotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Reciprocal Meiotic Recombination Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neutrophil Differentiation Histone H3-R26 Methylation Inner Cell Mass Cell Fate Commitment Nitrogen Compound Metabolic Process Positive Regulation Of Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Microtubule-based Process Female Meiosis Sister Chromatid Cohesion Resolution Of Mitotic Recombination Intermediates Resolution Of Recombination Intermediates Strand Invasion DNA Catabolic Process, Endonucleolytic Protein Stabilization Zonula Adherens Maintenance Cellular Response To Camptothecin Cellular Response To Hydroxyurea Cellular Macromolecule Catabolic Process Regulation Of Lymphocyte Activation Meiosis I Lymphocyte Activation Response To Camptothecin Negative Regulation Of Mitotic Recombination Microtubule Cytoskeleton Organization
Tagcloud ?		agree china cnki cochrane databases deletion derive efs eligible embase estimation ethnicity hazard infrastructure intervals lymphoblastic meta methodology precise pubmed random ratios science stratified subgroups unfavorable updated wanfang web	altogether anything atm brca2 brip1 chek2 confer dysfunctional exons germline harbor heritability hrr inherited junction missense palb2 paralogs postulated private silent splice substitutions tolerates unexplained variants xrcc2
Tagcloud (Difference) ?		agree china cnki cochrane databases deletion derive efs eligible embase estimation ethnicity hazard infrastructure intervals lymphoblastic meta methodology precise pubmed random ratios science stratified subgroups unfavorable updated wanfang web	altogether anything atm brca2 brip1 chek2 confer dysfunctional exons germline harbor heritability hrr inherited junction missense palb2 paralogs postulated private silent splice substitutions tolerates unexplained variants xrcc2
Tagcloud (Intersection) ?