IKZF1 and SNW1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		IKZF1	SNW1
Description		IKAROS family zinc finger 1	SNW domain containing 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol Protein-containing Complex	Nucleus Nucleoplasm Spliceosomal Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Matrix Nuclear Body Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding	Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Notch Binding Protein Binding Nuclear Receptor Binding Enzyme Binding Nuclear Vitamin D Receptor Binding Nuclear Retinoic Acid Receptor Binding SMAD Binding Nuclear Androgen Receptor Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Mesoderm Development Lymphocyte Differentiation Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid
Pathways			Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088 29296818) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 23512250 25310577 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29296818 29632299) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Area under the curve of insulin levels ( 24699409) Aspartate aminotransferase levels ( 29403010) Asthma ( 32296059) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement ( 25672763) Crohn's disease ( 21102463) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 32203549) Height ( 28552196) Hemoglobin ( 32888494) Hemoglobin levels ( 28017375) hemolysis of donated blood (osmotic) ( 34014839) High density lipoprotein cholesterol levels ( 29403010 33339817) Hippocampal atrophy ( 19668339) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 33536631) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular volume ( 19862010 27863252 28017375 28453575 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602) N-glycan levels ( 31163085) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 27863252 29403010 32888494) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Serum total protein levels ( 29403010) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 19838193 19838195 23273568 26502338 26663301 27399966 28714469) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 29403010 33339817) Type 1 diabetes ( 25751624)	Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Interacting Genes		107 interacting genes: AEN AIRIM ALKBH3 ANKRD11 ANKRD36 AP1M1 AP2M1 ARMC7 ATOSB BARD1 BYSL C1orf174 C8orf33 CBX8 CCDC185 CDC7 CDK2AP2 CDKL3 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CWF19L2 DCX DDB1 DDX6 DYRK2 FAM161A FAM50B FAM74A4 FGF12 FHL2 FOXP1 FRMD6 GLRX3 GMCL2 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LHX4 LMO1 LMO2 LMO3 LMO4 LSM4 MAD2L2 MAGOHB MAPRE3 MCRS1 MEOX2 MORF4L1 MORF4L2 MOS MPPED2 NEK6 NME7 NOC4L NUDT21 PIAS2 PIN1 PNKP PPL PRKAA2 PRKAB2 PRPF18 PSMA1 PSMA4 QARS1 RAD51D RBBP8 RBM43 RNF4 RNF6 RUNX1 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SHFL SIN3A SIN3B SMARCA4 SNRPA1 SNRPF SNW1 SPATC1L SYT17 TBP TCEA2 TDG TSTD2 TXK UBE2I USP7 ZMAT2 ZNF417 ZNF580 ZNF581 ZNF587	122 interacting genes: ABLIM3 ACTN2 APOBEC3C AR ASCC2 BAG4 BCAS2 BICD2 BYSL C1orf216 CCDC125 CEBPA CEP55 CEP70 CIRSR CPSF7 CSDE1 CTBP1 CWF19L2 DAXX DMRTB1 EP300 ERCC3 EXOSC5 EXOSC7 EXOSC8 FAM90A1 FTSJ3 GABPB1 GAS2L2 GOLGA2 GRIPAP1 HDAC2 HMBOX1 HOOK1 HOOK2 HSF2BP IKBKG IKZF1 JDP2 KANK2 KRT31 KRT40 LRP2BP LZTS2 MAGEA1 MAGOHB MAPK6 MCMBP MEN1 MFAP1 MISP MSL1 MTUS2 NCK2 NCOA1 NCOR1 NCOR2 NIN NOTCH1 NOTCH3 NR0B1 NR0B2 NXF1 OCLN ODF2 OGT OSTF1 PABPN1 PCBD2 PEG10 PGR PICK1 PPIL1 PRKAA2 PRKAR1B RABEP1 RARA RB1 RBFOX2 RBL1 RBL2 RBM22 RBPJ RBPMS RINT1 RXRA SAAL1 SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SNU13 SPECC1L STEEP1 SUMO2 TCP11L1 TEX11 TFIP11 THOC1 TNNT1 TOP1 TRAF1 TRAK1 TRIM15 TRIM23 TRIM55 TRIM63 TSNAXIP1 TTC14 TXNL4A USF1 USO1 VAV2 VDR VIM VPS39 WBP4 ZSCAN1
Entrez ID		10320	22938
HPRD ID		04318	04340
Ensembl ID		ENSG00000185811	ENSG00000100603
Uniprot IDs		A0A2R8Y4D3 A0A2R8YFR0 A0A8V8TNQ0 C9JTB0 Q13422 R9R4D9	G3V3A4 Q13573
PDB IDs		6H0F 8D7Z 8D80 8RQC 8TNP 8TNQ 8TNR	5MQF 5XJC 5YZG 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein Binding Sin3-type Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Androgen Receptor Signaling Pathway Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process NuRD Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process PML Body Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Cell Fate Specification Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA Metabolic Process Nuclear Speck U2-type Precatalytic Spliceosome Chromatin Organization RNA Splicing Negative Regulation Of Metabolic Process Protein K6-linked Ubiquitination DNA Repair	Nucleoplasm RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Domain Specific Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Cytoplasm Chromatin Binding Chromatin Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II RNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process MRNA Splicing, Via Spliceosome
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