PAX8 and PKM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PAX8	PKM
Description		paired box 8	pyruvate kinase M1/2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Activity RNA Binding MRNA Binding Catalytic Activity Protein Tyrosine Kinase Activity Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Histone H3T11 Kinase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding
	Biological Process	Urogenital System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Sensory Organ Development Anatomical Structure Morphogenesis Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development S-shaped Body Morphogenesis Kidney Epithelium Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion	Glycolytic Process Chromatin Remodeling Regulation Of Translation Programmed Cell Death Cellular Response To Insulin Stimulus Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation
Pathways		Formation of intermediate mesoderm Formation of the nephric duct	Neutrophil degranulation Negative Regulation of CDH1 Gene Transcription
Drugs			Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Indoprofen Copper Polydatin Artenimol
Diseases		Congenital nongoitrous hypothyroidism (CHNG) Thyroid cancer
GWAS		Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Cervical intraepithelial neoplasia grade 3 ( 33794208) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208) Creatinine levels ( 29403010) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Language functional connectivity ( 34929384) Lymphocyte count ( 27863252) Mucinous ovarian carcinoma ( 26075790) Optic disc size ( 31809533) Renal function-related traits (BUN) ( 22797727) Sleep duration ( 27992416 27494321 25469926) Sleep duration (long sleep) ( 30846698) Sleep duration (oversleepers vs undersleepers) ( 27494321) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416) Urate levels ( 31578528) Weight ( 28552196)	Aspartate aminotransferase levels ( 33547301)
Interacting Genes		24 interacting genes: ANXA7 AURKA CDK3 CHUK CXCL9 DOK4 EP300 GCM2 HNF1B HOXC8 HOXC9 ID2 LONRF1 NFIC NFIX NKX2-1 PKM POU2AF1 SAE1 SERINC1 SKP2 SMAD3 SS18L1 WBP2	71 interacting genes: ANXA7 APP ARAF ARX AURKB CCR4 CDC25A CDK4 CEBPA CLIC6 CTNNB1 DANCR DDX39B DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 FXR1 FXR2 GRB7 HERC1 HIF1A HOXA1 HSP90AA1 HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MBNL1 MDM2 MECOM MYL2 MYOC NAGK NDRG1 NXT2 OGT OLFM2 OTUB2 PAX8 PDE4B PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 STUB1 SUMO1 SUMO2 TERF1 TINF2 TK1 TP53 TRIM35 TRIM63 UBE3A UCHL5 USP7 YWHAQ
Entrez ID		7849	5315
HPRD ID		01335	01529
Ensembl ID		ENSG00000125618	ENSG00000067225
Uniprot IDs		Q06710 R9W7C9	A0A804F6T5 A0A804F729 A0A8V8TNX9 B4DNK4 P14618 V9HWB8
PDB IDs		2K27	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6 7L21 8G2E 8HGF 8HMQ 8HMR 8HMS 8HMU 8X4R
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Animal Organ Morphogenesis Regulation Of Primary Metabolic Process Chromatin Pattern Specification Process Positive Regulation Of Metabolic Process Regionalization Anterior/posterior Pattern Specification Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thigmotaxis Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Endoderm Development Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Embryonic Organ Morphogenesis DNA-binding Transcription Factor Activity Gland Development Mesonephric Tubule Development Negative Regulation Of Transcription By RNA Polymerase II Mesonephric Epithelium Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Tube Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Kidney Epithelium Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Virus Developmental Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cell Differentiation Response To Virus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding	Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Telomere Maintenance Regulation Of Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Signal Transduction Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Signaling Cassette Nucleoplasm Response To Xenobiotic Stimulus Glutamatergic Synapse Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Chromosome Organization Regulation Of DNA Metabolic Process ERBB Signaling Pathway Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle
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