PAX8 and DOK4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PAX8	DOK4
Name		paired box 8	docking protein 4
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Urogenital System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Sensory Organ Development Anatomical Structure Morphogenesis Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development S-shaped Body Morphogenesis Kidney Epithelium Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Positive Regulation Of MAPK Cascade
Pathways		Formation of intermediate mesoderm Formation of the nephric duct	RET signaling
Diseases		Congenital nongoitrous hypothyroidism (CHNG) Thyroid cancer	None
GWAS		Blood urea nitrogen levels ( 31152163 ) Body mass index ( 28552196 ) Cervical intraepithelial neoplasia grade 3 ( 33794208 ) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208 ) Creatinine levels ( 29403010 ) Depressive symptom (sleep problems) (binary trait) ( 31530331 ) Diastolic blood pressure ( 30224653 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Glomerular filtration rate ( 29403010 ) Language functional connectivity ( 34929384 ) Lymphocyte count ( 27863252 ) Mucinous ovarian carcinoma ( 26075790 ) Optic disc size ( 31809533 ) Renal function-related traits (BUN) ( 22797727 ) Sleep duration ( 27992416 27494321 25469926 ) Sleep duration (long sleep) ( 30846698 ) Sleep duration (oversleepers vs undersleepers) ( 27494321 ) Sleep duration (short sleep) ( 30846698 ) Sleep traits (multi-trait analysis) ( 27992416 ) Urate levels ( 31578528 ) Weight ( 28552196 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: SLIT2	None recorded
Interacting Genes		24 interacting genes: ANXA7 AURKA CDK3 CHUK CXCL9 DOK4 EP300 GCM2 HNF1B HOXC8 HOXC9 ID2 LONRF1 NFIC NFIX NKX2-1 PKM POU2AF1 SAE1 SERINC1 SKP2 SMAD3 SS18L1 WBP2	21 interacting genes: CRK EGFR ERBB2 FYN IGF1R INCA1 INSR LIX1 MAPRE3 OLIG1 OPRM1 PAX8 PFDN5 PTK2 RASA1 RBP7 RET RHOU SRC STAT2 TEK
Entrez ID		7849	55715
HPRD ID		01335	16316
Ensembl ID		ENSG00000125618	ENSG00000125170
Uniprot IDs		Q06710 R9W7C9	H3BQ19 Q8TEW6
PDB IDs		2K27	Not available
GO Terms Enriched among Interactors		Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Animal Organ Morphogenesis Regulation Of Primary Metabolic Process Chromatin Pattern Specification Process Positive Regulation Of Metabolic Process Regionalization Anterior/posterior Pattern Specification Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thigmotaxis Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Endoderm Development Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Embryonic Organ Morphogenesis DNA-binding Transcription Factor Activity Gland Development Mesonephric Tubule Development Negative Regulation Of Transcription By RNA Polymerase II Mesonephric Epithelium Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Tube Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Kidney Epithelium Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Virus Developmental Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cell Differentiation Response To Virus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Ephrin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Developmental Process Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Positive Regulation Of Intracellular Signal Transduction Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Receptor Complex Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Cell Motility Dendritic Spine Maintenance Positive Regulation Of Locomotion Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Shape Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Binding Signal Transduction Regulation Of Cell Motility Response To Growth Factor Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Locomotion Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Adhesion ERBB2 Signaling Pathway Protein Phosphorylation