PAX8 and ANXA7

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		PAX8	ANXA7
Gene Name		paired box 8	annexin A7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Chromaffin Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Transcription Regulatory Region DNA Binding	Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Central Nervous System Development Anatomical Structure Morphogenesis Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion	Cellular Calcium Ion Homeostasis Autophagy Hemostasis Cell Proliferation Regulation Of Cell Shape Response To Salt Stress Cellular Water Homeostasis Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Epithelial Cell Differentiation Social Behavior Response To Calcium Ion Membrane Fusion
Pathways
Drugs
Diseases
GWAS		Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		11 interactors: ANXA7 CHUK CXCL9 EP300 ID2 NKX2-1 PKM POU2AF1 SERINC1 SMAD3 WBP2	108 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CPSF3L CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 INPP5K KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS RBBP4 RBM48 RPA1 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TP53 TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431
Entrez ID		7849	310
HPRD ID		01335	01720
Ensembl ID		ENSG00000125618	ENSG00000138279
Uniprot IDs		Q06710 R9W7C9	B2R657 P20073
PDB IDs		2K27
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Mammary Gland Epithelial Cell Proliferation Tissue Development Organ Morphogenesis Thyroid Gland Development Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Cell Differentiation Regulation Of Metabolic Process Immune Response Immune System Process Negative Regulation Of Gene Expression Regulation Of Binding Negative Regulation Of Osteoblast Differentiation Mammary Gland Lobule Development Mammary Gland Alveolus Development Tube Development Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Digestive Tract Morphogenesis Response To Lipid Transcription From RNA Polymerase II Promoter Histone H2B Acetylation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cytokine Production Response To Organic Cyclic Compound Negative Regulation Of Ossification Positive Regulation Of Type I Interferon Production Oligodendrocyte Differentiation Somitogenesis Neuron Fate Commitment Endoderm Development Epithelial Cell Proliferation Protein Stabilization Response To External Stimulus	Anatomical Structure Development Multicellular Organismal Development Developmental Process System Development Cellular Metabolic Process Metabolic Process Cellular Response To Organic Substance Platelet Activation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Blood Coagulation Response To Growth Factor Programmed Cell Death Hemostasis Negative Regulation Of Cellular Protein Metabolic Process Cell Death Catabolic Process Death Response To Organic Substance Apoptotic Process Histone H3-T6 Phosphorylation Regulation Of Apoptotic Process Nervous System Development Regulation Of Body Fluid Levels Negative Regulation Of Protein Metabolic Process Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Regulation Of Proteolysis Mitotic Cell Cycle Process Negative Regulation Of Glucose Transport Organelle Organization Cell Activation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Cellular Process Regulation Of Cellular Response To Insulin Stimulus Wound Healing Cellular Response To Stimulus Regulation Of Proteasomal Protein Catabolic Process Gene Expression Protein Metabolic Process Mitotic Cell Cycle Organ Development Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization
Tagcloud ?		absent agenesis ch congenital consequence dysgenesis ectopic ectopically familial gland hypoplasia hypothalamic hypothyroidism implicate initiated neurological newborns occasionally paired permanent pituitary presumably severely siblings sporadic stimulating td though thyroid	annexin anticancer antitumor chinese cytotoxic cytotoxicity decreasing depressed dramatically eecp ethanol exerted explored huvecs kappa mb mcf mda mitochondrial mu obviously p65 possess propolis ros umbilical upregulating vein
Tagcloud (Difference) ?		absent agenesis ch congenital consequence dysgenesis ectopic ectopically familial gland hypoplasia hypothalamic hypothyroidism implicate initiated neurological newborns occasionally paired permanent pituitary presumably severely siblings sporadic stimulating td though thyroid	annexin anticancer antitumor chinese cytotoxic cytotoxicity decreasing depressed dramatically eecp ethanol exerted explored huvecs kappa mb mcf mda mitochondrial mu obviously p65 possess propolis ros umbilical upregulating vein
Tagcloud (Intersection) ?