PAX8 and NKX2-1

Number of citations of the paper that reports this interaction (PMID 14970209)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PAX8	NKX2-1
Gene Name		paired box 8	NK2 homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Transcription Regulatory Region DNA Binding	Core Promoter Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Central Nervous System Development Anatomical Structure Morphogenesis Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Transcription From RNA Polymerase II Promoter Phospholipid Metabolic Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Forebrain Neuron Fate Commitment Cerebral Cortex GABAergic Interneuron Differentiation Pituitary Gland Development Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Anatomical Structure Formation Involved In Morphogenesis Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Clara Cell Differentiation Type II Pneumocyte Differentiation
Pathways
Drugs
Diseases
GWAS		Renal function-related traits (BUN) ( 22797727)	Height ( 18391950) Menarche (age at onset) ( 23667675) Thyroid cancer ( 19198613)
Protein-Protein Interactions		11 interactors: ANXA7 CHUK CXCL9 EP300 ID2 NKX2-1 PKM POU2AF1 SERINC1 SMAD3 WBP2	14 interactors: CALR CREBBP GATA6 HIPK2 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 PTRF RARA RELA TDG WWTR1
Entrez ID		7849	7080
HPRD ID		01335	02798
Ensembl ID		ENSG00000125618	ENSG00000136352
Uniprot IDs		Q06710 R9W7C9	P43699
PDB IDs		2K27
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Mammary Gland Epithelial Cell Proliferation Tissue Development Organ Morphogenesis Thyroid Gland Development Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Cell Differentiation Regulation Of Metabolic Process Immune Response Immune System Process Negative Regulation Of Gene Expression Regulation Of Binding Negative Regulation Of Osteoblast Differentiation Mammary Gland Lobule Development Mammary Gland Alveolus Development Tube Development Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Digestive Tract Morphogenesis Response To Lipid Transcription From RNA Polymerase II Promoter Histone H2B Acetylation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cytokine Production Response To Organic Cyclic Compound Negative Regulation Of Ossification Positive Regulation Of Type I Interferon Production Oligodendrocyte Differentiation Somitogenesis Neuron Fate Commitment Endoderm Development Epithelial Cell Proliferation Protein Stabilization Response To External Stimulus	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Biosynthetic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Regulation Of Nitrogen Compound Metabolic Process Response To Hormone Intracellular Receptor Signaling Pathway Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Gland Development Response To Organic Substance Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organ Morphogenesis Embryonic Morphogenesis Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Tissue Development Anatomical Structure Morphogenesis Response To Estrogen Regulation Of Metabolic Process Response To Steroid Hormone Positive Regulation Of Cell Proliferation
Tagcloud ?		absent agenesis ch congenital consequence dysgenesis ectopic ectopically familial gland hypoplasia hypothalamic hypothyroidism implicate initiated neurological newborns occasionally paired permanent pituitary presumably severely siblings sporadic stimulating td though thyroid
Tagcloud (Difference) ?		absent agenesis ch congenital consequence dysgenesis ectopic ectopically familial gland hypoplasia hypothalamic hypothyroidism implicate initiated neurological newborns occasionally paired permanent pituitary presumably severely siblings sporadic stimulating td though thyroid
Tagcloud (Intersection) ?