PAX8 and WBP2

Number of citations of the paper that reports this interaction (PMID 14531730)
1

Data Source:
HPRD (in vivo, in vitro)

		PAX8	WBP2
Gene Name		paired box 8	WW domain binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Chromatin
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity Protein Binding Chromatin DNA Binding
	Biological Process	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Central Nervous System Development Anatomical Structure Morphogenesis Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion	Establishment Of Protein Localization Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estrogen Stimulus Positive Regulation Of Histone H3-K14 Acetylation
Pathways
Drugs
Diseases
GWAS		Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		11 interactors: ANXA7 CHUK CXCL9 EP300 ID2 NKX2-1 PKM POU2AF1 SERINC1 SMAD3 WBP2	10 interactors: CLEC4G ITCH MAGEA4 MAGI1 NEDD4 PAX8 SEPT3 WWP1 WWP2 YAP1
Entrez ID		7849	23558
HPRD ID		01335	06097
Ensembl ID		ENSG00000125618	ENSG00000132471
Uniprot IDs		Q06710 R9W7C9	A6NG10 B4DFG2 Q969T9
PDB IDs		2K27
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Mammary Gland Epithelial Cell Proliferation Tissue Development Organ Morphogenesis Thyroid Gland Development Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Cell Differentiation Regulation Of Metabolic Process Immune Response Immune System Process Negative Regulation Of Gene Expression Regulation Of Binding Negative Regulation Of Osteoblast Differentiation Mammary Gland Lobule Development Mammary Gland Alveolus Development Tube Development Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Digestive Tract Morphogenesis Response To Lipid Transcription From RNA Polymerase II Promoter Histone H2B Acetylation Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cytokine Production Response To Organic Cyclic Compound Negative Regulation Of Ossification Positive Regulation Of Type I Interferon Production Oligodendrocyte Differentiation Somitogenesis Neuron Fate Commitment Endoderm Development Epithelial Cell Proliferation Protein Stabilization Response To External Stimulus	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Interaction With Host Protein K63-linked Ubiquitination Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Protein Polyubiquitination Negative Regulation Of Cellular Metabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Regulation Of Stem Cell Maintenance Viral Life Cycle Protein Modification By Small Protein Conjugation Regulation Of Potassium Ion Transmembrane Transporter Activity Protein Catabolic Process Negative Regulation Of Stem Cell Differentiation Regulation Of Potassium Ion Transmembrane Transport Cellular Macromolecule Catabolic Process Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Regulation Of Thyroid-stimulating Hormone Secretion Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Metanephric DCT Cell Differentiation Locomotion Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Biosynthetic Process Positive Regulation Of Thyroid Hormone Generation Kidney Rudiment Formation Cellular Response To Radiation Regulation Of Epithelial Cell Differentiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport
Tagcloud ?		absent agenesis ch congenital consequence dysgenesis ectopic ectopically familial gland hypoplasia hypothalamic hypothyroidism implicate initiated neurological newborns occasionally paired permanent pituitary presumably severely siblings sporadic stimulating td though thyroid	athanogene bag3 bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a sgsm3 tumorigenic unchanged wbp2nl ww wwox wwp1 wwtr1 yap1 yes
Tagcloud (Difference) ?		absent agenesis ch congenital consequence dysgenesis ectopic ectopically familial gland hypoplasia hypothalamic hypothyroidism implicate initiated neurological newborns occasionally paired permanent pituitary presumably severely siblings sporadic stimulating td though thyroid	athanogene bag3 bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a sgsm3 tumorigenic unchanged wbp2nl ww wwox wwp1 wwtr1 yap1 yes
Tagcloud (Intersection) ?