RPH3AL and TCEA3

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		RPH3AL	TCEA3
Name		rabphilin 3A like (without C2 domains)	transcription elongation factor A3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Presynapse	Nucleus
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Exocytosis G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Secretion Glucose Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II
GWAS		AIDS progression ( 21502085 ) DHEAS levels ( 34748635 ) Dimensional psychopathology (Cognitive) ( 29496196 ) Idiopathic intracranial hypertension ( 29608535 ) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001 )	Adventurousness ( 30643258 ) Apolipoprotein A1 levels ( 32203549 ) Creatinine levels ( 29403010 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Eosinophil percentage of white cells ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) HDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) QT interval ( 24952745 29213071 29874175 ) Severe insulin-resistant type 2 diabetes ( 34737425 ) Total cholesterol levels ( 30275531 ) Triglycerides ( 30275531 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		26 interacting genes: AIRIM ANKRD11 ATPAF2 HNRNPK KHDRBS3 MID2 MYO15B PNMA3 PRKAB2 PSME3 RAB27A RAB27B RAB3A RAB3B RAB3C RAB3D RAB3GAP1 RAB8A RIMS2 RSPH14 SAAL1 SCNM1 SNCA TCEA3 UNC13B ZYX	2 interacting genes: LEO1 RPH3AL
Entrez ID		9501	6920
HPRD ID		05345	16036
Ensembl ID		ENSG00000181031	ENSG00000204219
Uniprot IDs		A8K7D5 Q9UNE2	B4DUM4 O75764 S4R3M9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Myosin V Binding Exocytosis Regulation Of Exocytosis GTP-dependent Protein Binding Secretion By Cell Secretion Regulation Of Secretion By Cell Regulation Of Secretion Synaptic Vesicle Regulation Of Vesicle-mediated Transport Positive Regulation Of Exocytosis Positive Regulation Of Secretion By Cell Vesicle-mediated Transport In Synapse GTPase Activity Positive Regulation Of Secretion Regulated Exocytosis GTP Binding Regulation Of Regulated Secretory Pathway Synaptic Vesicle Membrane Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Priming Vesicle-mediated Transport GDP Binding Regulation Of Transport Regulation Of Neurotransmitter Secretion Synaptic Vesicle Exocytosis Secretory Granule Calcium-ion Regulated Exocytosis Establishment Of Vesicle Localization Protein Domain Specific Binding Positive Regulation Of Transport Synaptic Vesicle Transport Acrosomal Vesicle Exocytosis Terminal Bouton Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Presynaptic Active Zone Vesicle Localization Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Regulated Secretory Pathway Organelle Localization Regulation Of Synaptic Vesicle Exocytosis Maintenance Of Presynaptic Active Zone Structure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Protein Localization Endosome Presynaptic Active Zone Organization Vesicle Docking	Calcium-dependent Activation Of Synaptic Vesicle Fusion Endodermal Cell Fate Commitment Cdc73/Paf1 Complex RNA Polymerase II C-terminal Domain Phosphoserine Binding Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Vesicle Fusion