RPH3AL and RAB27B

Number of citations: 0 (PubMedID 12578829)
Data Source: HPRD (in vivo)

		RPH3AL	RAB27B
Name		rabphilin 3A like (without C2 domains)	RAB27B, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Presynapse	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Exocytosis G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Secretion Glucose Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		None	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
GWAS		AIDS progression ( 21502085 ) DHEAS levels ( 34748635 ) Dimensional psychopathology (Cognitive) ( 29496196 ) Idiopathic intracranial hypertension ( 29608535 ) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001 )	Adult body size ( 32376654 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Body mass index ( 28892062 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 26604143 ) Depression ( 29700475 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )
Interacting Genes		26 interacting genes: AIRIM ANKRD11 ATPAF2 HNRNPK KHDRBS3 MID2 MYO15B PNMA3 PRKAB2 PSME3 RAB27A RAB27B RAB3A RAB3B RAB3C RAB3D RAB3GAP1 RAB8A RIMS2 RSPH14 SAAL1 SCNM1 SNCA TCEA3 UNC13B ZYX	10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D
Entrez ID		9501	5874
HPRD ID		05345	04846
Ensembl ID		ENSG00000181031	ENSG00000041353
Uniprot IDs		A8K7D5 Q9UNE2	O00194
PDB IDs		Not available	2F7S
GO Terms Enriched among Interactors		Myosin V Binding Exocytosis Regulation Of Exocytosis GTP-dependent Protein Binding Secretion By Cell Secretion Regulation Of Secretion By Cell Regulation Of Secretion Synaptic Vesicle Regulation Of Vesicle-mediated Transport Positive Regulation Of Exocytosis Positive Regulation Of Secretion By Cell Vesicle-mediated Transport In Synapse GTPase Activity Positive Regulation Of Secretion Regulated Exocytosis GTP Binding Regulation Of Regulated Secretory Pathway Synaptic Vesicle Membrane Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Priming Vesicle-mediated Transport GDP Binding Regulation Of Transport Regulation Of Neurotransmitter Secretion Synaptic Vesicle Exocytosis Secretory Granule Calcium-ion Regulated Exocytosis Establishment Of Vesicle Localization Protein Domain Specific Binding Positive Regulation Of Transport Synaptic Vesicle Transport Acrosomal Vesicle Exocytosis Terminal Bouton Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Presynaptic Active Zone Vesicle Localization Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Regulated Secretory Pathway Organelle Localization Regulation Of Synaptic Vesicle Exocytosis Maintenance Of Presynaptic Active Zone Structure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Protein Localization Endosome Presynaptic Active Zone Organization Vesicle Docking	Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel