RPH3AL and RAB3B

Number of citations of the paper that reports this interaction (PubMedID 15159548)
41

Data Source:
HPRD (in vitro, in vivo)

		RPH3AL	RAB3B
Description		rabphilin 3A like (without C2 domains)	RAB3B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Presynapse	Cytoplasm Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Dopaminergic Synapse
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Exocytosis G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Secretion Glucose Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion	Exocytosis Protein Transport Regulation Of Exocytosis Antigen Processing And Presentation Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Vesicle Size Regulation Of Synaptic Vesicle Cycle
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS		AIDS progression ( 21502085) DHEAS levels ( 34748635) Dimensional psychopathology (Cognitive) ( 29496196) Idiopathic intracranial hypertension ( 29608535) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001)	Mean platelet volume ( 32888494)
Interacting Genes		26 interacting genes: AIRIM ANKRD11 ATPAF2 HNRNPK KHDRBS3 MID2 MYO15B PNMA3 PRKAB2 PSME3 RAB27A RAB27B RAB3A RAB3B RAB3C RAB3D RAB3GAP1 RAB8A RIMS2 RSPH14 SAAL1 SCNM1 SNCA TCEA3 UNC13B ZYX	15 interacting genes: ACVR1 CALM1 CALM2 CALM3 CHM GDI1 PIGR RIMS2 RPH3A RPH3AL SGSM2 SMAD1 SMAD4 TGFBR1 VRTN
Entrez ID		9501	5865
HPRD ID		05345	01540
Ensembl ID		ENSG00000181031	ENSG00000169213
Uniprot IDs		A8K7D5 Q9UNE2	P20337
PDB IDs			3DZ8 8A4B 8A4C
Enriched GO Terms of Interacting Partners?		Myosin V Binding Exocytosis Regulation Of Exocytosis GTP-dependent Protein Binding Secretion By Cell Secretion Regulation Of Secretion By Cell Regulation Of Secretion Synaptic Vesicle Regulation Of Vesicle-mediated Transport Positive Regulation Of Exocytosis Positive Regulation Of Secretion By Cell Vesicle-mediated Transport In Synapse GTPase Activity Positive Regulation Of Secretion Regulated Exocytosis GTP Binding Regulation Of Regulated Secretory Pathway Synaptic Vesicle Membrane Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Priming Vesicle-mediated Transport GDP Binding Regulation Of Transport Regulation Of Neurotransmitter Secretion Synaptic Vesicle Exocytosis Secretory Granule Calcium-ion Regulated Exocytosis Establishment Of Vesicle Localization Protein Domain Specific Binding Positive Regulation Of Transport Synaptic Vesicle Transport Acrosomal Vesicle Exocytosis Terminal Bouton Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Presynaptic Active Zone Vesicle Localization Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Regulated Secretory Pathway Organelle Localization Regulation Of Synaptic Vesicle Exocytosis Maintenance Of Presynaptic Active Zone Structure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Protein Localization Endosome Presynaptic Active Zone Organization Vesicle Docking	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Adenylate Cyclase Activator Activity Myelin Sheath Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Small GTPase Binding Vesicle-mediated Transport Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling I-SMAD Binding Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Negative Regulation Of Transporter Activity Calcium Channel Complex Transforming Growth Factor Beta Receptor Signaling Pathway Protein-containing Complex Calcineurin-mediated Signaling Activin Receptor Signaling Pathway Detection Of Chemical Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intracellular Signaling Cassette Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Synaptic Vesicle Membrane Response To Calcium Ion Transmembrane Transporter Binding Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Spindle Microtubule Transforming Growth Factor Beta Receptor Activity, Type I Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development Calcium Channel Regulator Activity SMAD Binding Sperm Midpiece Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Spontaneous Neurotransmitter Secretion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?