RPH3AL and PNMA3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RPH3AL	PNMA3
Name		rabphilin 3A like (without C2 domains)	PNMA family member 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Presynapse	Nucleus Nucleolus
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Exocytosis G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Secretion Glucose Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion	Positive Regulation Of Apoptotic Process
GWAS		AIDS progression ( 21502085 ) DHEAS levels ( 34748635 ) Dimensional psychopathology (Cognitive) ( 29496196 ) Idiopathic intracranial hypertension ( 29608535 ) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001 )	No GWAS studies recorded
Interacting Genes		26 interacting genes: AIRIM ANKRD11 ATPAF2 HNRNPK KHDRBS3 MID2 MYO15B PNMA3 PRKAB2 PSME3 RAB27A RAB27B RAB3A RAB3B RAB3C RAB3D RAB3GAP1 RAB8A RIMS2 RSPH14 SAAL1 SCNM1 SNCA TCEA3 UNC13B ZYX	12 interacting genes: APTX C19orf25 CCDC187 CNNM3 LNX1 PRPF31 RPH3AL SLC25A37 SMG9 TIGD3 UBQLN2 ZBTB47
Entrez ID		9501	29944
HPRD ID		05345	06677
Ensembl ID		ENSG00000181031	ENSG00000183837
Uniprot IDs		A8K7D5 Q9UNE2	Q9UL41
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Myosin V Binding Exocytosis Regulation Of Exocytosis GTP-dependent Protein Binding Secretion By Cell Secretion Regulation Of Secretion By Cell Regulation Of Secretion Synaptic Vesicle Regulation Of Vesicle-mediated Transport Positive Regulation Of Exocytosis Positive Regulation Of Secretion By Cell Vesicle-mediated Transport In Synapse GTPase Activity Positive Regulation Of Secretion Regulated Exocytosis GTP Binding Regulation Of Regulated Secretory Pathway Synaptic Vesicle Membrane Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Priming Vesicle-mediated Transport GDP Binding Regulation Of Transport Regulation Of Neurotransmitter Secretion Synaptic Vesicle Exocytosis Secretory Granule Calcium-ion Regulated Exocytosis Establishment Of Vesicle Localization Protein Domain Specific Binding Positive Regulation Of Transport Synaptic Vesicle Transport Acrosomal Vesicle Exocytosis Terminal Bouton Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Presynaptic Active Zone Vesicle Localization Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Regulated Secretory Pathway Organelle Localization Regulation Of Synaptic Vesicle Exocytosis Maintenance Of Presynaptic Active Zone Structure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Protein Localization Endosome Presynaptic Active Zone Organization Vesicle Docking	None