SIT1 and CSK

Number of citations of the paper that reports this interaction (PMID 11433379)
10

Data Source:
HPRD (in vivo)

		SIT1	CSK
Gene Name		signaling threshold regulating transmembrane adaptor 1	c-src tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Kinase Binding SH2 Domain Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Identical Protein Binding Proline-rich Region Binding
	Biological Process	Immune System Process Signal Transduction Regulation Of T Cell Activation	Regulation Of Cytokine Production Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Cell Differentiation Platelet Activation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus
Pathways			Costimulation by the CD28 family GAB1 signalosome Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFR TCR signaling Signaling by EGFR in Cancer PD-1 signaling Platelet activation, signaling and aggregation Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs			Staurosporine
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065)	Blood pressure ( 21909110) Caffeine consumption ( 21490707) Diastolic blood pressure ( 19430479 19430483) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		7 interactors: CSK FYN GRB2 LCK PTPN11 SYK ZAP70	46 interactors: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDH5 CREBBP DAB2 DOK1 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 ZAP70 ZNF212
Entrez ID		27240	1445
HPRD ID		05394	00496
Ensembl ID		ENSG00000137078	ENSG00000103653
Uniprot IDs		Q9Y3P8	A8K3B6 B2R6Q4 P41240
PDB IDs			1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Leukocyte Migration T Cell Costimulation Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Blood Coagulation Hemostasis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Platelet Activation Protein Autophosphorylation Locomotion Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Wound Healing Defense Response Positive Regulation Of Immune Response Cell Activation Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Response To Wounding Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction T Cell Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cell Adhesion Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Immune System Process Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Intracellular Signal Transduction Leukocyte Migration Positive Regulation Of Cellular Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Response To Wounding Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Wound Healing Negative Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune Response Innate Immune Response
Tagcloud ?		bgd1 eai eai1 eai2 eai5 eai6 guadeloupe kelantan kuala lumpur malaysia manila mtbc mys nonthaburi pasteur phylogeographical sit19 sit236 sit256 sit50 sit591 sit745 sit89 sits sitvit2 som spacers spoligo	associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections
Tagcloud (Difference) ?		bgd1 eai eai1 eai2 eai5 eai6 guadeloupe kelantan kuala lumpur malaysia manila mtbc mys nonthaburi pasteur phylogeographical sit19 sit236 sit256 sit50 sit591 sit745 sit89 sits sitvit2 som spacers spoligo	associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections
Tagcloud (Intersection) ?