SIT1 and ITM2A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SIT1	ITM2A
Description		signaling threshold regulating transmembrane adaptor 1	integral membrane protein 2A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding Kinase Binding SH2 Domain Binding	Amyloid-beta Binding Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Signal Transduction T Cell Homeostasis Regulation Of T Cell Activation	Plasma Cell Differentiation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065)	Birth weight ( 31043758) Graves' disease ( 23612905) Height ( 18391951) Nose size ( 27182965) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781)
Interacting Genes		17 interacting genes: APOL2 BMP10 CLRN2 CSK FYN GRB2 ITM2A LCK MALL PLN PTPN11 SYK TMBIM6 TMEM140 TSPAN33 UPK1B ZAP70	7 interacting genes: CLDN7 FCGR1A FNDC9 MEOX2 SIT1 TMED9 TRIM14
Entrez ID		27240	9452
HPRD ID		05394	02200
Ensembl ID		ENSG00000137078	ENSG00000078596
Uniprot IDs		Q9Y3P8	O43736
PDB IDs
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Leukocyte Activation Immune Response-activating Signaling Pathway Phospholipase Binding Cell Activation Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Beta Selection Cellular Developmental Process Cell Differentiation T Cell Receptor Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Immune System Process T Cell Activation Protein Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Proliferation Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Regulation Of MAPK Cascade
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