SIT1

Name	signaling threshold regulating transmembrane adaptor 1
Structure	No pdb structure
Novel Interactors	1 novel interactors: CDKN2A
Interactors	17 interactors: APOL2 BMP10 CLRN2 CSK FYN GRB2 ITM2A LCK MALL PLN PTPN11 SYK TMBIM6 TMEM140 TSPAN33 UPK1B ZAP70
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Kinase Binding SH2 Domain Binding
	Biological Process	Adaptive Immune Response Immune System Process Signal Transduction T Cell Homeostasis Regulation Of T Cell Activation
GWAS	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065 )
Entrez ID	27240
HPRD ID	05394
Ensembl ID	ENSG00000137078
Uniprot IDs	Q9Y3P8
PDB IDs	Not available
GO Terms Enriched among Interactors ?	T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Leukocyte Activation Immune Response-activating Signaling Pathway Phospholipase Binding Cell Activation Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Beta Selection Cellular Developmental Process Cell Differentiation T Cell Receptor Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Immune System Process T Cell Activation Protein Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Proliferation Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Regulation Of MAPK Cascade