SIT1 and APOL2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SIT1	APOL2
Name		signaling threshold regulating transmembrane adaptor 1	apolipoprotein L2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Cytoplasm Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Kinase Binding SH2 Domain Binding	Signaling Receptor Binding Protein Binding High-density Lipoprotein Particle Binding Lipid Binding
	Biological Process	Adaptive Immune Response Immune System Process Signal Transduction T Cell Homeostasis Regulation Of T Cell Activation	Lipid Metabolic Process Lipid Transport Acute-phase Response Cholesterol Metabolic Process Lipoprotein Metabolic Process Maternal Process Involved In Female Pregnancy
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065 )	Epigenetic age acceleration in alcohol use disorder ( 31466081 )
Interacting Genes		17 interacting genes: APOL2 BMP10 CLRN2 CSK FYN GRB2 ITM2A LCK MALL PLN PTPN11 SYK TMBIM6 TMEM140 TSPAN33 UPK1B ZAP70	38 interacting genes: AIG1 APOC2 APOC4 AR BSND CISD2 CYBC1 EBAG9 ELOVL4 EMP1 ERGIC3 FAM209A FAM210B GET1 GJB5 ITGB2 KCNA1 LMNA MARCHF3 MFF MGST3 PANX1 PSCA SFXN5 SIT1 SLC18A1 SLC26A6 SLC35H1 STX1A STX2 TIMMDC1 TMED8 TMEM139 TMEM45B TMEM52B TMEM60 USE1 YIPF6
Entrez ID		27240	23780
HPRD ID		05394	06263
Ensembl ID		ENSG00000137078	ENSG00000128335
Uniprot IDs		Q9Y3P8	Q9BQE5
PDB IDs		Not available	7LF8
GO Terms Enriched among Interactors		T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Leukocyte Activation Immune Response-activating Signaling Pathway Phospholipase Binding Cell Activation Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Beta Selection Cellular Developmental Process Cell Differentiation T Cell Receptor Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Immune System Process T Cell Activation Protein Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Proliferation Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Regulation Of MAPK Cascade	Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex