SIT1 and TSPAN33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SIT1	TSPAN33
Description		signaling threshold regulating transmembrane adaptor 1	tetraspanin 33
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Adherens Junction Cell Surface Membrane Pore Complex Anchoring Junction Tetraspanin-enriched Microdomain
	Molecular Function	Protein Binding Kinase Binding SH2 Domain Binding	Protein Binding Enzyme Binding
	Biological Process	Adaptive Immune Response Immune System Process Signal Transduction T Cell Homeostasis Regulation Of T Cell Activation	Pore Complex Assembly Protein Maturation Protein Localization To Plasma Membrane
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065)	Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 23128233)
Interacting Genes		17 interacting genes: APOL2 BMP10 CLRN2 CSK FYN GRB2 ITM2A LCK MALL PLN PTPN11 SYK TMBIM6 TMEM140 TSPAN33 UPK1B ZAP70	27 interacting genes: CHRM2 CISD2 CLDN7 COQ9 DARS2 ERGIC3 FAM209A GAD2 GJA8 GORAB GPR152 GPX8 KCNK5 LHFPL5 LMNA MFF MGST3 MTIF3 NEMP1 PLEKHO1 RELL2 SHISA4 SIT1 SLC35H1 SPINT1 TMEM106C TMEM45B
Entrez ID		27240	340348
HPRD ID		05394	14669
Ensembl ID		ENSG00000137078	ENSG00000158457
Uniprot IDs		Q9Y3P8	Q86UF1
PDB IDs
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Leukocyte Activation Immune Response-activating Signaling Pathway Phospholipase Binding Cell Activation Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Beta Selection Cellular Developmental Process Cell Differentiation T Cell Receptor Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Immune System Process T Cell Activation Protein Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Proliferation Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Regulation Of MAPK Cascade	Membrane
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