DUSP3 and SYK

Number of citations of the paper that reports this interaction (PMID 12447358)
18

Data Source:
HPRD (in vitro, in vivo)

		DUSP3	SYK
Gene Name		dual specificity phosphatase 3	spleen tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane B Cell Receptor Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Early Phagosome T Cell Receptor Complex Protein Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Integrin Binding Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Inactivation Of MAPK Activity In Utero Embryonic Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Peptidyl-tyrosine Dephosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Stress-activated MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade	Angiogenesis Lymph Vessel Development Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Serotonin Secretion By Platelet Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Blood Coagulation Cell Proliferation Organ Morphogenesis Regulation Of Platelet Activation Viral Process Leukotriene Biosynthetic Process Platelet Activation Neutrophil Chemotaxis Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Transcription Factor Import Into Nucleus Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Regulation Of Arachidonic Acid Secretion Regulation Of Platelet Aggregation
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Signaling by the B Cell Receptor (BCR) FCERI mediated MAPK activation Platelet Aggregation (Plug Formation) DAP12 signaling Regulation of signaling by CBL Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System DAP12 interactions Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade Interleukin-2 signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs			Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic Acid
Diseases
GWAS			Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)
Protein-Protein Interactions		14 interactors: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 NEUROD1 PDGFA STAT1 SYK ZAP70	98 interactors: APP BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CRKL CSF2RB CSF3R CTTN DBNL DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HNRNPU IL15RA IL2RB ITGB2 JAK1 LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2
Entrez ID		1845	6850
HPRD ID		02553	02514
Ensembl ID		ENSG00000108861	ENSG00000165025
Uniprot IDs		P51452	A8K4G2 P43405
PDB IDs		1J4X 1VHR 3F81	1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG
Enriched GO Terms of Interacting Partners?		Innate Immune Response Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Neurotrophin Signaling Pathway Immune System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of MAP Kinase Activity Regulation Of Immune System Process Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Activation Of MAPKK Activity Chemotaxis Regulation Of Golgi Inheritance Platelet Activation Positive Regulation Of Macromolecule Biosynthetic Process Cell Activation Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Organ Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Phosphorylation MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process System Development Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Locomotion	Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Defense Response Fc Receptor Signaling Pathway Immune Response Signal Transduction Cellular Response To Organic Substance Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Positive Regulation Of Immune Response Signaling Positive Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Neurotrophin Signaling Pathway Intracellular Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus ERBB Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Activation Response To Wounding Blood Coagulation Hemostasis Wound Healing Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Leukocyte Activation Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Platelet Activation Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		abilities abrogated contributor deaths demethylase demethylases demethylation dephosphorylates dimethylated dynamically dysregulation emerged epigenetic erk1 fbxl11 h3k36 invasiveness jhdm1a kdm2a methyltransferases modifier modifiers modulated nsclc tumorigenesis uncover unexpected worldwide xenograft	belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 src tandem tyrosine tyrosines ut7
Tagcloud (Difference) ?		abilities abrogated contributor deaths demethylase demethylases demethylation dephosphorylates dimethylated dynamically dysregulation emerged epigenetic erk1 fbxl11 h3k36 invasiveness jhdm1a kdm2a methyltransferases modifier modifiers modulated nsclc tumorigenesis uncover unexpected worldwide xenograft	belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 src tandem tyrosine tyrosines ut7
Tagcloud (Intersection) ?