DUSP3 and CASK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DUSP3	CASK
Description		dual specificity phosphatase 3	calcium/calmodulin dependent serine protein kinase
Image
GO Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cilium Motile Cilium Cell Projection	Basement Membrane Nucleus Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Nuclear Matrix Cell Junction Vesicle Presynaptic Membrane Synapse Ciliary Membrane Cell Periphery Schaffer Collateral - CA1 Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity Protein Kinase Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Tyrosine Kinase Binding	Nucleotide Binding GMP Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Neurexin Family Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Signal Transduction Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly	Negative Regulation Of Cell-matrix Adhesion Cell Adhesion Intracellular Protein Localization Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Regulation Of Neurotransmitter Secretion Establishment Of Localization In Cell Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis
Pathways		ERKs are inactivated	Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs			Formic acid Fostamatinib
Diseases			FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) High density lipoprotein cholesterol levels ( 33339817) Metabolite levels ( 23823483) Triglycerides ( 25961943)
Interacting Genes		15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70	90 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L CADM1 CASKIN1 CDK9 CIMIP1 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A RSPH1 SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TIAM1 TRIM22 TSPYL2 UBC WHRN WNT7B YWHAE
Entrez ID		1845	8573
HPRD ID		02553	02164
Ensembl ID		ENSG00000108861	ENSG00000147044
Uniprot IDs		P51452	A0A2R8YE77 A0A2U3TZM1 A0A7I2RJN6 O14936
PDB IDs		1J4X 1VHR 3F81 8TK2 8TK3 8TK4 8TK5 8TK6 9DJ9	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH 7OAI 7OAJ 7OAK 7OAL
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Golgi Inheritance Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Trachea Formation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Protein Kinase Activity Positive Regulation Of Protein Metabolic Process ERK1 And ERK2 Cascade Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Epithelial Cell Proliferation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Golgi Organization	Neuroligin Family Protein Binding Glutamatergic Synapse PDZ Domain Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Cell Projection Microtubule-based Process Intracellular Protein Localization Regulation Of Membrane Potential Positive Regulation Of Cellular Component Biogenesis Vocalization Behavior Neurotransmitter Secretion Learning Cellular Component Assembly Protein Localization To Cell Junction Social Behavior Cell Adhesion Presynaptic Membrane Microtubule Cytoskeleton Organization Protein Localization To Synapse Regulation Of Cytoskeleton Organization Cytoskeleton Organization Chemical Synaptic Transmission Neurotransmitter Transport Regulation Of System Process Cell-cell Junction Regulation Of Transport MPP7-DLG1-LIN7 Complex Trans-synaptic Signaling Learning Or Memory Regulation Of Monoatomic Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Exosomal Secretion Regulation Of Multicellular Organismal Process Voltage-gated Potassium Channel Complex Postsynaptic Membrane Plasma Membrane Neuromuscular Junction Presynapse Protein Kinase Binding Regulation Of Biological Quality Bicellular Tight Junction Protein Localization To Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?