DUSP3

Description		dual specificity phosphatase 3
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GO Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cilium Motile Cilium Cell Projection
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity Protein Kinase Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Signal Transduction Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly
Pathways		ERKs are inactivated
Drugs
Diseases
GWAS		Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) High density lipoprotein cholesterol levels ( 33339817) Metabolite levels ( 23823483) Triglycerides ( 25961943)
Interacting Genes		15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70
Entrez ID		1845
HPRD ID		02553
Ensembl ID		ENSG00000108861
Uniprot IDs		P51452
PDB IDs		1J4X 1VHR 3F81 8TK2 8TK3 8TK4 8TK5 8TK6 9DJ9
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Golgi Inheritance Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Trachea Formation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Protein Kinase Activity Positive Regulation Of Protein Metabolic Process ERK1 And ERK2 Cascade Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Epithelial Cell Proliferation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Golgi Organization
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