DUSP3 and NEUROD1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DUSP3	NEUROD1
Gene Name		dual specificity phosphatase 3	neuronal differentiation 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Inactivation Of MAPK Activity In Utero Embryonic Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Peptidyl-tyrosine Dephosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Stress-activated MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Transcription, DNA-templated Nucleocytoplasmic Transport Nitric Oxide Mediated Signal Transduction Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Endocrine Pancreas Development Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Response To Drug Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JAK-STAT Cascade Embryonic Organ Morphogenesis Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Regulation of beta-cell development Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Regulation of gene expression in beta cells
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 NEUROD1 PDGFA STAT1 SYK ZAP70	12 interactors: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 PDX1 PITX1 RREB1 TCF4
Entrez ID		1845	4760
HPRD ID		02553	03428
Ensembl ID		ENSG00000108861	ENSG00000162992
Uniprot IDs		P51452	Q13562
PDB IDs		1J4X 1VHR 3F81
Enriched GO Terms of Interacting Partners?		Innate Immune Response Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Neurotrophin Signaling Pathway Immune System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of MAP Kinase Activity Regulation Of Immune System Process Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Activation Of MAPKK Activity Chemotaxis Regulation Of Golgi Inheritance Platelet Activation Positive Regulation Of Macromolecule Biosynthetic Process Cell Activation Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Organ Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Phosphorylation MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process System Development Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Locomotion	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cation Channel Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cellular Biosynthetic Process Second-messenger-mediated Signaling Positive Regulation Of Metabolic Process Glucose Metabolic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Metabolic Process Intracellular Signal Transduction Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Hexose Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transport Neurotrophin Signaling Pathway Polysaccharide Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Secretion By Cell Positive Regulation Of Nitric-oxide Synthase Activity Cell Surface Receptor Signaling Pathway Monosaccharide Metabolic Process Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Catabolic Process Positive Regulation Of Calcium Ion Transport Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Central Nervous System Development Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Response To Stress Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance
Tagcloud ?		abilities abrogated contributor deaths demethylase demethylases demethylation dephosphorylates dimethylated dynamically dysregulation emerged epigenetic erk1 fbxl11 h3k36 invasiveness jhdm1a kdm2a methyltransferases modifier modifiers modulated nsclc tumorigenesis uncover unexpected worldwide xenograft	aa ad1 ad2 beta2 carboxy cbp chimeras coactivator constructs convert creb ectoderm ectopic embryos evolutionarily gal4 helix implicate islet morphogenesis precursors premature separable spanning transactivation utilized xenopus
Tagcloud (Difference) ?		abilities abrogated contributor deaths demethylase demethylases demethylation dephosphorylates dimethylated dynamically dysregulation emerged epigenetic erk1 fbxl11 h3k36 invasiveness jhdm1a kdm2a methyltransferases modifier modifiers modulated nsclc tumorigenesis uncover unexpected worldwide xenograft	aa ad1 ad2 beta2 carboxy cbp chimeras coactivator constructs convert creb ectoderm ectopic embryos evolutionarily gal4 helix implicate islet morphogenesis precursors premature separable spanning transactivation utilized xenopus
Tagcloud (Intersection) ?