DUSP3 and FGF7

Number of citations of the paper that reports this interaction (PMID 1281549)
23

Data Source:
HPRD (in vitro)

		DUSP3	FGF7
Gene Name		dual specificity phosphatase 3	fibroblast growth factor 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	Extracellular Region Golgi Apparatus
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Inactivation Of MAPK Activity In Utero Embryonic Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Peptidyl-tyrosine Dephosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Stress-activated MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FGFR2 ligand binding and activation FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS			Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)
Protein-Protein Interactions		14 interactors: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 NEUROD1 PDGFA STAT1 SYK ZAP70	13 interactors: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 UBQLN1
Entrez ID		1845	2252
HPRD ID		02553	01022
Ensembl ID		ENSG00000108861
Uniprot IDs		P51452	P21781 Q6FGV5
PDB IDs		1J4X 1VHR 3F81
Enriched GO Terms of Interacting Partners?		Innate Immune Response Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Neurotrophin Signaling Pathway Immune System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of MAP Kinase Activity Regulation Of Immune System Process Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Activation Of MAPKK Activity Chemotaxis Regulation Of Golgi Inheritance Platelet Activation Positive Regulation Of Macromolecule Biosynthetic Process Cell Activation Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Organ Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Phosphorylation MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process System Development Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Locomotion	Cellular Response To Growth Factor Stimulus Response To Growth Factor Tissue Development Extracellular Matrix Disassembly Cellular Response To Organonitrogen Compound Cellular Response To Organic Substance Skeletal System Morphogenesis Axonogenesis Bone Morphogenesis Ossification Skeletal System Development Endochondral Ossification Axon Development Cell Morphogenesis Involved In Neuron Differentiation Organ Morphogenesis Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Embryo Development Cell Morphogenesis Involved In Differentiation Collagen Catabolic Process Inner Ear Development Response To Organic Substance Regulation Of ERK1 And ERK2 Cascade Cartilage Development Neurotrophin TRK Receptor Signaling Pathway Head Development Neuron Projection Development Collagen Metabolic Process Otic Vesicle Development Neurotrophin Signaling Pathway Response To Organonitrogen Compound Cell Projection Morphogenesis Bone Development Endochondral Bone Morphogenesis Regulation Of Signal Transduction Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Ear Development Cell Part Morphogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Metabolic Process Connective Tissue Development Blood Vessel Development Vasculature Development Peptidyl-tyrosine Phosphorylation Inner Ear Morphogenesis Neuron Development Central Nervous System Development
Tagcloud ?		abilities abrogated contributor deaths demethylase demethylases demethylation dephosphorylates dimethylated dynamically dysregulation emerged epigenetic erk1 fbxl11 h3k36 invasiveness jhdm1a kdm2a methyltransferases modifier modifiers modulated nsclc tumorigenesis uncover unexpected worldwide xenograft	abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces
Tagcloud (Difference) ?		abilities contributor deaths demethylase demethylases demethylation dephosphorylates dimethylated dynamically dysregulation emerged epigenetic erk1 fbxl11 h3k36 invasiveness jhdm1a kdm2a methyltransferases modifier modifiers nsclc tumorigenesis uncover unexpected worldwide xenograft	abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces
Tagcloud (Intersection) ?		abrogated modulated