KCNK3 and SFN

Number of citations of the paper that reports this interaction (PMID 12433946)
25

Data Source:
HPRD (two hybrid, in vivo)

		KCNK3	SFN
Gene Name		potassium channel, two pore domain subfamily K, member 3	stratifin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space Nucleus Cytoplasm Cytosol Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Ion Channel Activity Open Rectifier Potassium Channel Activity Potassium Channel Activity Protein C-terminus Binding Potassium Ion Leak Channel Activity Protein Homodimerization Activity S100 Protein Binding Protein Heterodimerization Activity	Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Phosphoprotein Binding
	Biological Process	Potassium Ion Transport Synaptic Transmission Brain Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Response To Drug Negative Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Zinc Ion Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Cochlea Development	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Release Of Cytochrome C From Mitochondria Keratinocyte Development Negative Regulation Of Protein Kinase Activity Apoptotic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Epidermal Cell Division Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cell Growth Keratinization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Protein Export From Nucleus Membrane Organization Establishment Of Skin Barrier Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		TWIK-releated acid-sensitive K+ channel (TASK) Tandem pore domain potassium channels Potassium Channels	Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: COPB1 S100A10 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	49 interactors: ABL1 BAD BAX BCR CCAR1 CCDC102B CCNH CDC25B CDK1 CHST1 EEF1A1 EGFR EIF2S1 EIF4B EXO1 FAM189A2 FAM53C FAM9B FOXO4 GPRIN2 HDAC5 HNRNPD ING1 KCNK15 KCNK3 KCNK9 KIAA0408 LONRF1 MAGEA1 MAP3K5 MARK3 MDM4 MKRN3 MST1R NR3C1 PLEKHF2 PLK4 RAB3IP RFFL RFWD2 SAMSN1 TBL3 TP53 TRIM25 TSC2 WDYHV1 YWHAG ZC2HC1C ZFP36
Entrez ID		3777	2810
HPRD ID		04451	03185
Ensembl ID			ENSG00000175793
Uniprot IDs		O14649	P31947
PDB IDs			1YWT 1YZ5 3IQJ 3IQU 3IQV 3LW1 3MHR 3O8I 3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SPR 3T0L 3T0M 3U9X 3UX0 4DAT 4DAU 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU 4FR3 4HQW 4HRU 4IEA 4JC3 4JDD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Intracellular Transport Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Cellular Protein Localization Regulation Of Protein Localization Establishment Of Protein Localization Intracellular Protein Transport Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Protein Localization Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Transport Cellular Localization Regulation Of Apoptotic Process Intracellular Transport Regulation Of Cell Death Protein Targeting Regulation Of Signal Transduction Substantia Nigra Development Intracellular Signal Transduction Regulation Of Signaling Neural Nucleus Development Establishment Of Localization In Cell Negative Regulation Of Protein Dephosphorylation Midbrain Development Transport Hippo Signaling Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dephosphorylation Organelle Organization	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Neuron Death Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Cell Cycle Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction ERBB Signaling Pathway Regulation Of Protein Kinase Activity Response To Stress Mitotic Cell Cycle Positive Regulation Of Cell Cycle Response To Organic Substance Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Catalytic Activity Cellular Response To Insulin Stimulus G2/M Transition Of Mitotic Cell Cycle Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cell Proliferation B Cell Activation Fc Receptor Signaling Pathway
Tagcloud ?		attenuation channels conductance dag determinants diacylglycerol downstream excitability galphaq gated gpcr gpcrs hormones initiated ip3 k2p kcnk9 links lipase messengers p2 phospholipase plc pore potassium subclass task transients transmitters	aging alarm amplitude auditory circuits cortico elderly electrophysiologically employed false finding frontal impairments latency limbic memory n4 p3 perform position potentials prefrontal recency serial sternberg subjects task working young
Tagcloud (Difference) ?		attenuation channels conductance dag determinants diacylglycerol downstream excitability galphaq gated gpcr gpcrs hormones initiated ip3 k2p kcnk9 links lipase messengers p2 phospholipase plc pore potassium subclass transients transmitters	aging alarm amplitude auditory circuits cortico elderly electrophysiologically employed false finding frontal impairments latency limbic memory n4 p3 perform position potentials prefrontal recency serial sternberg subjects working young
Tagcloud (Intersection) ?		task