KCNK3

Description		potassium two pore domain channel subfamily K member 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse
	Molecular Function	Monoatomic Ion Channel Activity Open Rectifier Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity S100 Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chemical Synaptic Transmission Response To Xenobiotic Stimulus Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Resting Membrane Potential Cellular Response To Zinc Ion Cellular Response To Hypoxia Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Cochlea Development Regulation Of Action Potential Firing Rate
Pathways		TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential
Drugs		Doxapram Halothane
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Apolipoprotein B levels ( 32203549) Body mass index ( 25673413 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518 29403010 28739976 27841878 27736895 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Hand grip strength ( 29691431) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) Hypertension ( 31879980 30487518) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 29403010 26390057 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Potassium levels ( 29403010) Pulse pressure ( 30487518 29403010 30578418 28739976 27841878) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 28739976 27618452 30578418 29403010 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549)
Interacting Genes		9 interacting genes: COPB1 S100A10 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		3777
HPRD ID		04451
Ensembl ID		ENSG00000171303
Uniprot IDs		O14649
PDB IDs		6RV2 6RV3 6RV4 9G9X
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Protein Sequestering Activity Protein Domain Specific Binding Intracellular Protein Localization Transmembrane Transporter Binding Establishment Of Protein Localization Protein Targeting Extracellular Exosome Protein Kinase C Inhibitor Activity Phosphoprotein Binding Focal Adhesion Substantia Nigra Development Identical Protein Binding Neural Nucleus Development Cadherin Binding Melanosome Regulation Of Nucleocytoplasmic Transport Insulin-like Growth Factor Receptor Binding Regulation Of Transport Regulation Of Protein Localization Positive Regulation Of Protein Export From Nucleus Regulation Of Intracellular Protein Transport Intracellular Signal Transduction Negative Regulation Of Immune System Process Negative Regulation Of Immune Response Negative Regulation Of Protein Localization Regulation Of Protein Export From Nucleus Protein Phosphatase Inhibitor Activity Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Regulation Of Intracellular Transport Cytoplasm Positive Regulation Of Nucleocytoplasmic Transport Cellular Localization Establishment Of Localization In Cell Negative Regulation Of TORC1 Signaling TORC1 Signaling Glucocorticoid Catabolic Process Cytosol Negative Regulation Of Protein Kinase Activity Intracellular Signaling Cassette Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Kinase Activity TOR Signaling Regulation Of Immune Response Positive Regulation Of Intracellular Protein Transport AnxA2-p11 Complex Enzyme Binding Regulation Of Heart Rate By Hormone Protein Phosphatase Binding
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