KCNK3 and YWHAH

Number of citations of the paper that reports this interaction (PubMedID 12433946)
40

Data Source:
HPRD (in vivo, two hybrid)

		KCNK3	YWHAH
Description		potassium two pore domain channel subfamily K member 3	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
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GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse
	Molecular Function	Monoatomic Ion Channel Activity Open Rectifier Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity S100 Protein Binding Metal Ion Binding Protein Heterodimerization Activity	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity
	Biological Process	Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chemical Synaptic Transmission Response To Xenobiotic Stimulus Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Resting Membrane Potential Cellular Response To Zinc Ion Cellular Response To Hypoxia Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Cochlea Development Regulation Of Action Potential Firing Rate	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Doxapram Halothane	Phenethyl Isothiocyanate
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Apolipoprotein B levels ( 32203549) Body mass index ( 25673413 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518 29403010 28739976 27841878 27736895 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Hand grip strength ( 29691431) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) Hypertension ( 31879980 30487518) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 29403010 26390057 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Potassium levels ( 29403010) Pulse pressure ( 30487518 29403010 30578418 28739976 27841878) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 28739976 27618452 30578418 29403010 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549)	Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		9 interacting genes: COPB1 S100A10 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		3777	7533
HPRD ID		04451	00215
Ensembl ID		ENSG00000171303	ENSG00000128245
Uniprot IDs		O14649	Q04917 Q9H4N8
PDB IDs		6RV2 6RV3 6RV4 9G9X	2C63 2C74 7NMZ
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Protein Sequestering Activity Protein Domain Specific Binding Intracellular Protein Localization Transmembrane Transporter Binding Establishment Of Protein Localization Protein Targeting Extracellular Exosome Protein Kinase C Inhibitor Activity Phosphoprotein Binding Focal Adhesion Substantia Nigra Development Identical Protein Binding Neural Nucleus Development Cadherin Binding Melanosome Regulation Of Nucleocytoplasmic Transport Insulin-like Growth Factor Receptor Binding Regulation Of Transport Regulation Of Protein Localization Positive Regulation Of Protein Export From Nucleus Regulation Of Intracellular Protein Transport Intracellular Signal Transduction Negative Regulation Of Immune System Process Negative Regulation Of Immune Response Negative Regulation Of Protein Localization Regulation Of Protein Export From Nucleus Protein Phosphatase Inhibitor Activity Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Regulation Of Intracellular Transport Cytoplasm Positive Regulation Of Nucleocytoplasmic Transport Cellular Localization Establishment Of Localization In Cell Negative Regulation Of TORC1 Signaling TORC1 Signaling Glucocorticoid Catabolic Process Cytosol Negative Regulation Of Protein Kinase Activity Intracellular Signaling Cassette Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Kinase Activity TOR Signaling Regulation Of Immune Response Positive Regulation Of Intracellular Protein Transport AnxA2-p11 Complex Enzyme Binding Regulation Of Heart Rate By Hormone Protein Phosphatase Binding	Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity
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